Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
16 fly	25GS	6.09e-01	2.94e-01	7.04e-01	3.67e-03
25GS	16 fly	3.03e-01	1.78e-01	5.57e-02	2.43e-01



Evaluating how well 16 fly genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
16 fly	25GS	0.71	0.92	2.43	0.77	3.15
25GS	16 fly	0.64	1.75	1.56	1.71	1.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
16 fly	25GS	0.00	0.44	1.47	-0.06	0.99
25GS	16 fly	0.00	0.09	0.33	0.14	-0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
16 fly	16	8	CYP4B1  ;SPHK1 ;TGM6 ;B3GALT5 ;ALPPL2 ;OVGP1 ;TTBK1 ;LRP3 
25GS	25	24	HLA -DRB1