Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
168PD	singleton GS	2.53e-02	1.31e-02	7.16e-02	1.22e-05
singleton GS	168PD	2.13e-01	3.97e-01	3.49e-12	4.40e-01



Evaluating how well 168PD genes are linked to singleton GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
168PD	singleton GS	0.82	2.50	3.56	2.32	4.65
singleton GS	168PD	0.53	2.36	1.74	1.92	1.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
168PD	singleton GS	0.01	3.85	7.03	3.37	0.73
singleton GS	168PD	0.01	6.24	3.50	1.83	1.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
168PD	168	167	AP000781.2
singleton GS	21	21