Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
168PD Exclusive	GWAS77	6.04e-01	4.79e-01	8.87e-01	5.62e-03
GWAS77 Exclusive	168PD	3.54e-01	1.58e-01	5.68e-05	3.62e-01
168PD Exclusive	GWAS77 Exclusive	5.33e-01	5.60e-01	7.30e-01	1.30e-03
GWAS77 Exclusive	168PD Exclusive	4.50e-01	3.76e-01	2.43e-04	4.62e-01
168PD Exclusive	Overlap	9.98e-01	9.90e-01	9.97e-01	9.30e-01
GWAS77 Exclusive	Overlap	1.11e-01	1.31e-01	1.73e-01	2.50e-01
Overlap	Exclusives	1.92e-02	1.05e-01	4.19e-01	1.01e-02



Evaluating how well 168PD genes are linked to GWAS77 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
168PD Exclusive	GWAS77	0.61	1.08	1.28	0.84	3.39
GWAS77 Exclusive	168PD	0.53	2.27	1.70	1.97	1.34
168PD Exclusive	GWAS77 Exclusive	0.62	1.32	1.19	0.98	3.58
GWAS77 Exclusive	168PD Exclusive	0.52	1.73	1.34	1.46	1.03
168PD Exclusive	Overlap	0.46	-0.11	0.17	-0.00	-0.31
GWAS77 Exclusive	Overlap	0.63	1.96	1.99	1.15	1.15
Overlap	Exclusives	0.56	1.38	2.39	1.76	3.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
168PD Exclusive	GWAS77	0.01	1.51	1.41	1.05	1.30
GWAS77 Exclusive	168PD	0.01	2.85	2.36	1.25	0.88
168PD Exclusive	GWAS77 Exclusive	0.01	2.01	1.73	1.15	4.78
GWAS77 Exclusive	168PD Exclusive	0.01	1.17	1.06	0.65	0.59
168PD Exclusive	Overlap	0.00	-0.29	-0.38	-0.29	-0.51
GWAS77 Exclusive	Overlap	0.01	27.17	31.95	19.55	7.68
Overlap	Exclusives	0.02	1.78	3.19	2.14	4.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
168PD Exclusive	162	161	AP000781.2
GWAS77 Exclusive	71	70	CASC16
Overlap	6	6