Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD140	singleton GS	9.89e-01	7.61e-01	1.40e-03	7.19e-04
singleton GS	PD140	3.87e-02	9.90e-01	4.36e-06	8.74e-05



Evaluating how well PD140 genes are linked to singleton GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD140	singleton GS	0.75	0.49	0.92	1.16	3.88
singleton GS	PD140	0.62	-0.26	0.10	0.61	4.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD140	singleton GS	0.00	-0.28	-115.76	1.22	3.81
singleton GS	PD140	0.01	0.39	0.20	1.84	4.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD140	141	140	RET
singleton GS	21	21