Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
174mu Exclusive	21ClinVar	4.53e-01	3.98e-01	2.62e-01	2.61e-04
21ClinVar Exclusive	174mu	4.48e-01	8.91e-01	1.50e-08	4.88e-01
174mu Exclusive	21ClinVar Exclusive	7.18e-01	4.04e-01	4.56e-01	1.53e-03
21ClinVar Exclusive	174mu Exclusive	4.99e-01	7.94e-01	6.81e-09	5.81e-01
174mu Exclusive	Overlap	5.40e-01	5.40e-01	2.66e-01	2.55e-02
21ClinVar Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.33e-02	1.17e-02	7.91e-34	4.43e-03



Evaluating how well 174mu genes are linked to 21ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
174mu Exclusive	21ClinVar	0.77	0.82	2.02	1.28	4.51
21ClinVar Exclusive	174mu	0.53	2.64	0.75	1.13	1.38
174mu Exclusive	21ClinVar Exclusive	0.75	0.56	1.76	0.92	3.74
21ClinVar Exclusive	174mu Exclusive	0.52	2.13	0.51	1.22	1.09
174mu Exclusive	Overlap	0.97	0.82	1.56	1.03	2.39
21ClinVar Exclusive	Overlap	1.00	1.82	1.90	2.07	2.16
Overlap	Exclusives	0.56	1.30	2.68	1.66	3.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
174mu Exclusive	21ClinVar	0.02	6.06	17.13	9.56	27.37
21ClinVar Exclusive	174mu	0.03	26.48	24.80	17.43	24.75
174mu Exclusive	21ClinVar Exclusive	0.01	3.96	11.81	6.08	8.74
21ClinVar Exclusive	174mu Exclusive	0.02	9.29	18.15	15.74	16.30
174mu Exclusive	Overlap	0.01	4.79	36.58	9.00	16.94
21ClinVar Exclusive	Overlap	0.09	160.61	724.66	76.68	184.45
Overlap	Exclusives	0.02	9.66	9.87	5.01	6.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
174mu Exclusive	172	168	RFPL2;SOS 2;AC004754.1;PRAMEF11
21ClinVar Exclusive	19	19	
Overlap	2	2