Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
134Mu Exclusive	GWAS39	3.41e-01	1.86e-01	4.17e-01	5.52e-03
GWAS39 Exclusive	134Mu	1.47e-01	1.11e-01	2.75e-02	2.87e-01
134Mu Exclusive	GWAS39 Exclusive	2.82e-01	3.19e-01	4.26e-01	5.20e-03
GWAS39 Exclusive	134Mu Exclusive	2.41e-01	1.46e-01	2.82e-02	1.91e-01
134Mu Exclusive	Overlap	7.54e-01	7.14e-01	8.11e-01	7.34e-01
GWAS39 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.49e-06	5.00e-06	1.77e-06	1.31e-06



Evaluating how well 134Mu genes are linked to GWAS39 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
134Mu Exclusive	GWAS39	0.67	1.46	2.42	1.33	3.28
GWAS39 Exclusive	134Mu	0.54	2.42	2.23	1.79	1.48
134Mu Exclusive	GWAS39 Exclusive	0.67	1.48	2.10	1.43	4.38
GWAS39 Exclusive	134Mu Exclusive	0.54	2.01	2.31	2.37	1.60
134Mu Exclusive	Overlap	0.50	-0.14	-0.11	-0.04	0.02
GWAS39 Exclusive	Overlap	1.00	1.86	1.87	2.04	1.73
Overlap	Exclusives	0.62	2.97	5.89	2.71	6.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
134Mu Exclusive	GWAS39	0.00	1.40	1.79	1.05	1.22
GWAS39 Exclusive	134Mu	0.01	2.85	2.89	0.95	2.14
134Mu Exclusive	GWAS39 Exclusive	0.00	1.13	1.65	1.27	3.84
GWAS39 Exclusive	134Mu Exclusive	0.01	0.92	1.33	1.49	1.44
134Mu Exclusive	Overlap	0.00	-0.38	-0.38	-0.32	-0.35
GWAS39 Exclusive	Overlap	0.07	21.36	44.91	40.17	69.65
Overlap	Exclusives	0.03	9.91	35.15	13.00	18.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
134Mu Exclusive	133	133	
GWAS39 Exclusive	38	37	HLA
Overlap	1	1