Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
216iDEAL Exclusive	CTD	4.21e-01	2.76e-01	4.82e-02	2.10e-14
CTD Exclusive	216iDEAL	2.09e-05	7.63e-01	5.06e-08	5.43e-01
216iDEAL Exclusive	CTD Exclusive	4.95e-01	2.59e-01	3.73e-02	1.76e-14
CTD Exclusive	216iDEAL Exclusive	2.44e-05	6.70e-01	2.97e-07	7.80e-01
216iDEAL Exclusive	Overlap	6.20e-01	7.01e-01	6.74e-01	9.88e-01
CTD Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.38e-04	3.80e-04	6.71e-19	9.71e-14



Evaluating how well 216iDEAL genes are linked to CTD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216iDEAL Exclusive	CTD	0.73	-0.43	0.33	0.22	7.23
CTD Exclusive	216iDEAL	0.52	-0.74	-0.72	0.04	1.09
216iDEAL Exclusive	CTD Exclusive	0.74	-0.26	0.67	0.38	7.54
CTD Exclusive	216iDEAL Exclusive	0.52	-0.90	-1.17	-0.40	0.49
216iDEAL Exclusive	Overlap	0.50	-0.96	-0.80	-1.19	0.03
CTD Exclusive	Overlap	1.00	2.84	2.15	2.49	2.31
Overlap	Exclusives	0.64	3.06	4.78	2.17	8.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216iDEAL Exclusive	CTD	0.02	-0.30	-1.44	0.44	16.96
CTD Exclusive	216iDEAL	0.01	2.34	1.74	1.46	2.32
216iDEAL Exclusive	CTD Exclusive	0.02	-0.29	-1.25	0.53	7.62
CTD Exclusive	216iDEAL Exclusive	0.01	-0.13	-0.55	-0.09	0.30
216iDEAL Exclusive	Overlap	0.00	-0.65	-0.46	-0.42	-0.14
CTD Exclusive	Overlap	0.08	211.49	405.41	250.15	232.23
Overlap	Exclusives	0.03	7.85	12.79	6.34	16.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
216iDEAL Exclusive	214	212	TUBB3;TTLL13
CTD Exclusive	101	87	MIR375;ATP7;MIR505;MIR100;CTR1B;SNAR-I;MIR296;MIR3622B;MIR146A;CTR1C;MIR4467;MIR708;MIR766;MIR124A-3
Overlap	2	2