Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
216iDEAL	ClinVar	7.89e-01	1.22e-01	3.53e-01	4.47e-05
ClinVar	216iDEAL	1.61e-04	7.51e-01	9.31e-06	2.32e-01



Evaluating how well 216iDEAL genes are linked to ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216iDEAL	ClinVar	0.78	1.13	1.90	1.12	4.67
ClinVar	216iDEAL	0.53	0.18	-0.16	-0.17	1.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216iDEAL	ClinVar	0.01	-0.19	-0.12	0.89	12.76
ClinVar	216iDEAL	0.01	1.16	1.41	1.49	1.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
216iDEAL	216	214	TTLL13;TUBB3
ClinVar	21	21