Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
216iDEAL Exclusive	DGN	1.42e-01	2.43e-01	1.08e-01	5.27e-12
DGN Exclusive	216iDEAL	1.07e-05	5.61e-02	1.34e-08	1.39e-01
216iDEAL Exclusive	DGN Exclusive	1.15e-01	3.61e-01	1.18e-01	2.03e-12
DGN Exclusive	216iDEAL Exclusive	4.20e-06	5.56e-02	2.74e-07	3.65e-01
216iDEAL Exclusive	Overlap	6.08e-01	4.06e-01	6.81e-01	5.21e-01
DGN Exclusive	Overlap	2.10e-05	6.99e-05	2.10e-05	4.51e-05
Overlap	Exclusives	3.82e-18	1.71e-19	2.16e-26	1.22e-29



Evaluating how well 216iDEAL genes are linked to DGN genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216iDEAL Exclusive	DGN	0.64	-1.08	-2.76	-0.47	6.98
DGN Exclusive	216iDEAL	0.52	-1.04	-1.13	-0.36	1.00
216iDEAL Exclusive	DGN Exclusive	0.65	-1.38	-2.00	-0.54	6.88
DGN Exclusive	216iDEAL Exclusive	0.51	-2.03	-1.75	-1.01	0.46
216iDEAL Exclusive	Overlap	0.55	-0.33	-0.45	-0.32	0.42
DGN Exclusive	Overlap	0.99	5.70	3.36	4.03	3.67
Overlap	Exclusives	0.68	4.61	12.51	3.85	14.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216iDEAL Exclusive	DGN	0.02	-0.67	-0.88	-0.02	7.80
DGN Exclusive	216iDEAL	0.01	5.21	2.87	2.39	3.78
216iDEAL Exclusive	DGN Exclusive	0.02	-0.93	-0.64	-0.00	9.30
DGN Exclusive	216iDEAL Exclusive	0.01	-1.11	-1.04	-0.49	0.27
216iDEAL Exclusive	Overlap	0.00	-0.44	-0.49	-0.47	-0.25
DGN Exclusive	Overlap	0.07	1168.34	261.66	240.81	206.61
Overlap	Exclusives	0.07	17.74	49.71	14.79	45.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
216iDEAL Exclusive	211	209	TTLL13;TUBB3
DGN Exclusive	203	200	DKK 1.00;PCDH11Y;SERPINA3
Overlap	5	5