Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
148Mu Exclusive	CTD	2.77e-01	8.77e-02	2.35e-02	2.61e-08
CTD Exclusive	148Mu	6.88e-04	4.52e-01	6.44e-06	6.74e-01
148Mu Exclusive	CTD Exclusive	4.67e-01	8.12e-02	3.07e-02	5.86e-08
CTD Exclusive	148Mu Exclusive	2.79e-04	6.89e-01	4.33e-05	5.33e-01
148Mu Exclusive	Overlap	7.44e-01	6.48e-01	7.02e-01	2.33e-01
CTD Exclusive	Overlap	7.88e-02	6.47e-02	2.95e-03	2.13e-02
Overlap	Exclusives	3.25e-08	4.74e-07	4.25e-24	8.17e-15



Evaluating how well 148Mu genes are linked to CTD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
148Mu Exclusive	CTD	0.70	0.17	-0.46	-0.39	6.08
CTD Exclusive	148Mu	0.50	-0.16	0.19	0.11	-0.02
148Mu Exclusive	CTD Exclusive	0.70	0.36	-0.76	-0.36	7.01
CTD Exclusive	148Mu Exclusive	0.49	-0.29	-0.16	-0.27	-0.44
148Mu Exclusive	Overlap	0.68	0.25	0.43	0.44	1.12
CTD Exclusive	Overlap	0.93	1.75	1.98	2.63	2.54
Overlap	Exclusives	0.66	2.44	5.84	2.21	7.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
148Mu Exclusive	CTD	0.01	-0.60	-2.89	-1.05	5.75
CTD Exclusive	148Mu	0.01	2.18	1.07	1.52	0.28
148Mu Exclusive	CTD Exclusive	0.01	-0.63	-2.65	-1.08	5.83
CTD Exclusive	148Mu Exclusive	0.01	-0.71	-0.26	-0.58	-0.74
148Mu Exclusive	Overlap	0.00	-0.34	-0.36	-0.32	-0.01
CTD Exclusive	Overlap	0.04	75.66	283.14	298.15	20.70
Overlap	Exclusives	0.03	9.66	14.36	7.10	16.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
148Mu Exclusive	145	143	WDR92;AC018755.2
CTD Exclusive	100	86	MIR296;CTR1B;CTR1C;MIR146A;MIR375;ATP7;MIR766;MIR100;MIR505;MIR4467;SNAR-I;MIR708;MIR3622B;MIR124A-3
Overlap	3	3