Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
70cohort Exclusive	25GS	7.11e-01	2.50e-01	7.15e-01	4.70e-02
25GS Exclusive	70cohort	2.54e-01	9.19e-01	4.32e-02	9.13e-01
70cohort Exclusive	25GS Exclusive	7.95e-01	2.31e-01	8.14e-01	1.90e-02
25GS Exclusive	70cohort Exclusive	2.47e-01	9.78e-01	5.43e-02	9.91e-01
70cohort Exclusive	Overlap	7.93e-01	7.14e-01	8.11e-01	7.34e-01
25GS Exclusive	Overlap	1.05e-01	9.92e-02	1.05e-01	1.12e-01
Overlap	Exclusives	7.98e-05	1.23e-02	5.21e-04	3.82e-03



Evaluating how well 70cohort genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
70cohort Exclusive	25GS	0.63	-0.19	0.86	0.23	2.15
25GS Exclusive	70cohort	0.50	0.89	0.43	0.55	0.04
70cohort Exclusive	25GS Exclusive	0.64	-0.02	0.92	0.09	2.76
25GS Exclusive	70cohort Exclusive	0.50	0.70	0.27	0.42	-0.04
70cohort Exclusive	Overlap	0.36	-0.21	-0.25	-0.17	-0.36
25GS Exclusive	Overlap	0.97	1.82	2.44	1.82	1.94
Overlap	Exclusives	0.55	1.31	2.03	1.20	2.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
70cohort Exclusive	25GS	0.00	-0.29	0.17	-0.18	0.69
25GS Exclusive	70cohort	0.01	0.65	-0.06	0.07	0.06
70cohort Exclusive	25GS Exclusive	0.00	-0.30	0.31	-0.21	0.44
25GS Exclusive	70cohort Exclusive	0.01	0.31	-0.26	0.04	-0.06
70cohort Exclusive	Overlap	0.00	-0.18	-0.44	-0.25	-0.15
25GS Exclusive	Overlap	0.00	1.01	30.87	1.39	0.21
Overlap	Exclusives	0.01	3.33	1.84	2.58	4.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
70cohort Exclusive	155	153	AC018755.2;WDR92
25GS Exclusive	24	24	
Overlap	1	1