Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
70 cohort Exclusive	DGN	7.63e-01	9.40e-01	9.20e-01	9.55e-11
DGN Exclusive	70 cohort	7.06e-03	6.10e-01	1.03e-04	5.83e-01
70 cohort Exclusive	DGN Exclusive	6.57e-01	8.56e-01	9.21e-01	2.90e-10
DGN Exclusive	70 cohort Exclusive	5.73e-03	5.85e-01	2.33e-04	4.56e-01
70 cohort Exclusive	Overlap	1.18e-01	9.92e-02	1.41e-01	7.14e-01
DGN Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	1.02e-19	6.21e-06	8.12e-67	7.74e-21



Evaluating how well 70 cohort genes are linked to DGN genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
70 cohort Exclusive	DGN	0.66	-0.05	0.62	0.39	7.75
DGN Exclusive	70 cohort	0.49	0.96	0.11	0.64	-0.20
70 cohort Exclusive	DGN Exclusive	0.66	-0.18	0.69	0.40	7.48
DGN Exclusive	70 cohort Exclusive	0.49	0.61	0.03	0.39	-0.56
70 cohort Exclusive	Overlap	0.60	-2.22	-1.79	-1.83	0.29
DGN Exclusive	Overlap	1.00	1.32	1.48	1.57	1.82
Overlap	Exclusives	0.66	1.78	7.34	1.93	12.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
70 cohort Exclusive	DGN	0.02	-0.16	0.51	0.11	8.18
DGN Exclusive	70 cohort	0.01	2.10	0.28	0.44	0.41
70 cohort Exclusive	DGN Exclusive	0.02	-0.22	0.56	0.04	9.57
DGN Exclusive	70 cohort Exclusive	0.01	1.15	-0.35	0.04	-0.18
70 cohort Exclusive	Overlap	0.00	-1.04	-1.00	-0.71	-0.20
DGN Exclusive	Overlap	0.01	4.31	14.59	24.64	5.43
Overlap	Exclusives	0.04	2.59	10.42	2.49	19.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
70 cohort Exclusive	155	153	WDR92;AC018755.2
DGN Exclusive	207	204	DKK 1.00;SERPINA3;PCDH11Y
Overlap	1	1