Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
70Cohort Exclusive	CLINVAR	7.54e-01	5.16e-01	5.96e-01	5.05e-03
CLINVAR Exclusive	70Cohort	1.34e-01	7.41e-01	4.68e-05	5.54e-01
70Cohort Exclusive	CLINVAR Exclusive	8.82e-01	5.26e-01	9.24e-01	1.90e-03
CLINVAR Exclusive	70Cohort Exclusive	1.50e-01	8.32e-01	2.26e-05	5.85e-01
70Cohort Exclusive	Overlap	9.92e-02	9.92e-02	1.12e-01	5.70e-01
CLINVAR Exclusive	Overlap	1.12e-01	9.92e-02	9.92e-02	1.49e-01
Overlap	Exclusives	3.79e-04	8.20e-01	2.13e-26	1.98e-01



Evaluating how well 70Cohort genes are linked to CLINVAR genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
70Cohort Exclusive	CLINVAR	0.70	-0.04	0.86	-0.09	3.83
CLINVAR Exclusive	70Cohort	0.49	0.87	-0.10	0.18	-0.55
70Cohort Exclusive	CLINVAR Exclusive	0.71	0.02	1.14	0.22	3.09
CLINVAR Exclusive	70Cohort Exclusive	0.49	0.59	-0.13	0.03	-0.67
70Cohort Exclusive	Overlap	0.60	-2.73	-2.06	-2.40	0.49
CLINVAR Exclusive	Overlap	0.96	0.34	1.55	1.54	1.64
Overlap	Exclusives	0.53	1.12	1.27	0.74	1.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
70Cohort Exclusive	CLINVAR	0.00	-0.46	-0.02	-0.48	1.88
CLINVAR Exclusive	70Cohort	0.01	0.32	-0.21	-0.15	-0.41
70Cohort Exclusive	CLINVAR Exclusive	0.00	-0.45	0.22	-0.31	0.24
CLINVAR Exclusive	70Cohort Exclusive	0.01	-0.09	-0.36	-0.22	-0.54
70Cohort Exclusive	Overlap	0.00	-0.97	-1.15	-0.60	-0.10
CLINVAR Exclusive	Overlap	0.00	-0.29	9.07	3.32	0.12
Overlap	Exclusives	0.01	0.50	-0.24	-0.11	0.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
70Cohort Exclusive	155	153	WDR92;AC018755.2
CLINVAR Exclusive	20	20	
Overlap	1	1