Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
88Mu Exclusive	DGN	5.18e-01	8.31e-01	6.61e-01	4.06e-10
DGN Exclusive	88Mu	6.10e-02	8.89e-01	5.76e-04	8.26e-01
88Mu Exclusive	DGN Exclusive	4.97e-01	5.49e-01	7.08e-01	1.62e-09
DGN Exclusive	88Mu Exclusive	5.25e-02	8.58e-01	3.12e-03	9.03e-01
88Mu Exclusive	Overlap	2.41e-01	2.80e-01	3.87e-01	3.80e-01
DGN Exclusive	Overlap	1.02e-02	1.02e-02	1.02e-02	1.02e-02
Overlap	Exclusives	1.79e-22	1.06e-33	1.36e-55	2.12e-51



Evaluating how well 88Mu genes are linked to DGN genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
88Mu Exclusive	DGN	0.64	0.27	0.06	0.04	7.83
DGN Exclusive	88Mu	0.51	0.95	-0.19	0.29	0.32
88Mu Exclusive	DGN Exclusive	0.64	0.40	0.30	0.11	6.53
DGN Exclusive	88Mu Exclusive	0.49	0.21	-0.47	-0.46	-0.31
88Mu Exclusive	Overlap	0.60	-0.45	-0.51	-0.09	0.70
DGN Exclusive	Overlap	0.93	3.92	2.03	3.20	2.90
Overlap	Exclusives	0.76	3.66	12.59	4.07	14.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
88Mu Exclusive	DGN	0.01	-0.43	-0.47	-0.49	4.43
DGN Exclusive	88Mu	0.03	121.52	57.34	20.24	44.26
88Mu Exclusive	DGN Exclusive	0.01	-0.36	-0.10	-0.46	4.33
DGN Exclusive	88Mu Exclusive	0.00	0.64	-0.10	-0.21	-0.41
88Mu Exclusive	Overlap	0.00	-0.68	-0.94	-0.52	-0.17
DGN Exclusive	Overlap	0.53	2609.23	446.97	1666.47	1481.64
Overlap	Exclusives	0.09	21.17	77.74	22.26	87.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
88Mu Exclusive	84	84	
DGN Exclusive	204	201	DKK 1.00;PCDH11Y;SERPINA3
Overlap	4	4