Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OMIM_MalaCard_ClinVar Exclusive	GWAS Catalog All	2.08e-08	9.08e-07	3.90e-87	5.25e-25
GWAS Catalog All Exclusive	OMIM_MalaCard_ClinVar	1.96e-13	7.87e-12	1.67e-18	2.70e-18
OMIM_MalaCard_ClinVar Exclusive	GWAS Catalog All Exclusive	2.83e-06	1.96e-05	2.59e-81	9.17e-24
GWAS Catalog All Exclusive	OMIM_MalaCard_ClinVar Exclusive	4.47e-04	5.98e-03	1.76e-06	4.69e-07
OMIM_MalaCard_ClinVar Exclusive	Overlap	4.06e-15	1.28e-14	4.06e-15	9.71e-15
GWAS Catalog All Exclusive	Overlap	6.66e-13	1.17e-11	4.95e-15	4.79e-14
Overlap	Exclusives	2.74e-21	7.97e-17	4.89e-39	5.01e-36



Evaluating how well OMIM_MalaCard_ClinVar genes are linked to GWAS Catalog All genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OMIM_MalaCard_ClinVar Exclusive	GWAS Catalog All	0.62	2.68	7.08	2.76	13.70
GWAS Catalog All Exclusive	OMIM_MalaCard_ClinVar	0.97	9.45	7.62	7.56	8.59
OMIM_MalaCard_ClinVar Exclusive	GWAS Catalog All Exclusive	0.61	2.70	6.55	2.55	11.33
GWAS Catalog All Exclusive	OMIM_MalaCard_ClinVar Exclusive	0.95	6.20	3.51	4.70	5.08
OMIM_MalaCard_ClinVar Exclusive	Overlap	0.97	3.23	8.15	4.43	6.81
GWAS Catalog All Exclusive	Overlap	0.98	7.69	6.74	6.77	7.09
Overlap	Exclusives	0.66	6.03	14.09	6.15	17.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OMIM_MalaCard_ClinVar Exclusive	GWAS Catalog All	0.10	11.43	25.88	13.17	36.51
GWAS Catalog All Exclusive	OMIM_MalaCard_ClinVar	0.24	295.69	243.21	381.32	650.77
OMIM_MalaCard_ClinVar Exclusive	GWAS Catalog All Exclusive	0.08	6.13	12.50	6.91	19.75
GWAS Catalog All Exclusive	OMIM_MalaCard_ClinVar Exclusive	0.01	5.36	7.88	13.27	31.51
OMIM_MalaCard_ClinVar Exclusive	Overlap	0.39	293.99	1166.04	718.32	981.79
GWAS Catalog All Exclusive	Overlap	0.33	714.24	452.81	818.82	396.70
Overlap	Exclusives	0.15	26.33	69.18	37.46	73.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OMIM_MalaCard_ClinVar Exclusive	11	11	
GWAS Catalog All Exclusive	1045	911	Y_RNA;AC005355.2;LOC105369709;LINC00538;LINC00348;LOC100506385;LY86-AS1;LOC101929457;DAOA-AS1;LOC101927394;LOC105372562;LINC00574;LOC107986166;ADH5P4;AP005482.1;AC004830.1;AL050132;LINC01192;YY1P2;LOC103312105;LOC101927450;PABPC1P2;LOC101928667;TYRL;LOC157273;LOC101927502;LINC00544;MTND4P7;SALL4P5;AL512306.3;AL139239.1;BCL2A;EIF3IP1;LOC101927866;CHCHD9;ATXN80S;LOC105370275;BC032874;SNHG17;THCAT155;LOC105370965;LOC440982;AS1;TOP1P1;LINC01162;TMEM75;GIMAP1-GIMAP5;OR51C1P;LOC729013;HMGB1P46;LINC01309;LOC105373670;SOCS5P5;SLC9A7P1;LRNN3;C5orf67;RMST;IG2BP2;C14orf70;C1ORF141;CDKAL;DMRTACPED11;CASC8;LOC102724511;C21orf54;EGFEM1P;AC068138.1;LOC100190940;LOC107987099;LOC401177;LOC105373585;SRGAP2D;LINC01310;LOC102724680;LOC102723886;LOC105370782;LINC01539;LINC00333;LINC00639;SLC25A51P1;LOC105372744;LINC00343;MTND2P8;LOC105374394;LOC107986143;INAFM2;HHEX-IDE;ST64GAL1;RPL32P23;LOC101928272;PCAT5;LYPD68;SNORD74B;LOC101928569;AS2;LOC72901;LINC01153;UBBP1;AK094733;BC037918;LINC00900;THEG5;GUCY2EP;LINC00693;LOC64673;LOC100288428;RPL19P16;BC038535;PVT1;LOC107986598;LOC101927363;LOC107986400;LOC105378797;ZC3H11B;HTR3A/B;NYAP2-IRS1;LINC00928;LOC101927735;RPS4XP9;LOC101927770;MEG3;SVIL2P;LOC105371270;LOC100506866;LOC105375508;MGC21675;LOC105371557;TLR12P;HMG1L1;CASC11;RPSAP52;TNK;LOC103344931;LOC285626
Overlap	18	18