Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OMIM Exclusive	GWAS_5e-8	4.35e-11	2.20e-07	5.17e-49	3.68e-18
GWAS_5e-8 Exclusive	OMIM	2.46e-15	1.15e-13	4.59e-19	3.00e-18
OMIM Exclusive	GWAS_5e-8 Exclusive	1.28e-07	8.50e-05	3.11e-48	1.71e-16
GWAS_5e-8 Exclusive	OMIM Exclusive	9.99e-04	1.34e-03	1.35e-06	3.55e-07
OMIM Exclusive	Overlap	5.15e-15	1.38e-14	4.76e-15	7.66e-15
GWAS_5e-8 Exclusive	Overlap	5.17e-14	1.88e-13	3.46e-15	1.38e-14
Overlap	Exclusives	4.35e-31	5.29e-27	7.49e-45	1.68e-43



Evaluating how well OMIM genes are linked to GWAS_5e-8 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OMIM Exclusive	GWAS_5e-8	0.64	2.91	6.78	3.16	12.02
GWAS_5e-8 Exclusive	OMIM	0.97	7.52	8.71	6.52	9.41
OMIM Exclusive	GWAS_5e-8 Exclusive	0.63	2.59	4.82	2.83	11.08
GWAS_5e-8 Exclusive	OMIM Exclusive	0.95	4.51	4.27	4.08	5.61
OMIM Exclusive	Overlap	0.97	3.44	6.66	4.24	6.64
GWAS_5e-8 Exclusive	Overlap	0.99	6.93	6.30	6.15	7.45
Overlap	Exclusives	0.71	8.03	15.62	7.95	18.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OMIM Exclusive	GWAS_5e-8	0.09	21.15	44.93	24.58	49.79
GWAS_5e-8 Exclusive	OMIM	0.40	330.83	416.90	477.79	884.15
OMIM Exclusive	GWAS_5e-8 Exclusive	0.06	9.25	16.62	11.13	26.74
GWAS_5e-8 Exclusive	OMIM Exclusive	0.02	7.14	23.19	9.68	70.25
OMIM Exclusive	Overlap	0.39	273.98	923.04	707.56	929.34
GWAS_5e-8 Exclusive	Overlap	0.57	795.10	847.68	1093.14	1661.07
Overlap	Exclusives	0.18	53.35	124.81	70.37	154.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OMIM Exclusive	11	11	
GWAS_5e-8 Exclusive	586	530	INAFM2;LOC102723886;RMST;LINC01162;AC068138.1;LOC107986166;LOC101927450;TYRL;BCL2A;LOC107986598;SVIL2P;LOC105378797;MGC21675;LOC105370965;MEG3;AP005482.1;AS1;LOC105370275;CASC8;LINC01153;LOC107986143;LOC64673;LOC105371557;ZC3H11B;HHEX-IDE;RPSAP52;LOC105373585;BCL6-LPP;LOC157273;C2CD4A/B;SRGAP2D;LINC00333;C5orf67;LOC105372562;EGFEM1P;PABPC1P2;LOC107987099;RPS4XP9;PVT1;CHCHD9;IG2BP2;UBBP1;RP11-554A11.7;RPL32P23;LOC105375508;NYAP2-IRS1;AC004830.1;LOC105369709;AL512306.3;CASC11;LOC101927502;LOC101929457;AC005355.2;MTND2P8;RP11-587H10.2;SLC25A51P1
Overlap	18	18