Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91Mu Exclusive	GS25	8.38e-01	9.10e-01	5.60e-01	2.62e-01
GS25 Exclusive	91Mu	9.04e-01	5.13e-01	1.31e-01	3.30e-01
91Mu Exclusive	GS25 Exclusive	8.26e-01	9.26e-01	9.58e-01	3.20e-01
GS25 Exclusive	91Mu Exclusive	7.55e-01	6.54e-01	2.57e-01	4.46e-01
91Mu Exclusive	Overlap	4.16e-01	7.12e-01	6.05e-01	9.58e-01
GS25 Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	5.30e-02	4.59e-02	1.69e-10	5.62e-03



Evaluating how well 91Mu genes are linked to GS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91Mu Exclusive	GS25	0.58	-0.13	-0.56	-0.46	1.46
GS25 Exclusive	91Mu	0.54	1.21	0.80	1.16	1.39
91Mu Exclusive	GS25 Exclusive	0.59	0.53	-0.26	0.01	1.38
GS25 Exclusive	91Mu Exclusive	0.52	0.52	0.73	0.39	0.90
91Mu Exclusive	Overlap	0.52	-1.26	-1.05	-0.88	0.05
GS25 Exclusive	Overlap	1.00	2.81	2.38	2.92	3.50
Overlap	Exclusives	0.59	3.17	3.16	2.09	2.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91Mu Exclusive	GS25	0.00	-0.45	-0.64	-0.74	-0.08
GS25 Exclusive	91Mu	0.01	5.03	7.32	5.77	2.67
91Mu Exclusive	GS25 Exclusive	0.00	-0.06	-0.58	-0.42	-0.05
GS25 Exclusive	91Mu Exclusive	0.00	-0.15	0.53	-0.24	-0.06
91Mu Exclusive	Overlap	0.00	-0.81	-0.31	-0.79	-0.15
GS25 Exclusive	Overlap	0.09	179.61	183.77	309.91	247.77
Overlap	Exclusives	0.04	55.21	54.71	36.02	41.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91Mu Exclusive	88	88	
GS25 Exclusive	22	21	HLA -DRB1
Overlap	3	3