Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91Mu Exclusive	CTD	5.48e-01	6.13e-01	1.65e-01	1.57e-07
CTD Exclusive	91Mu	3.39e-02	7.98e-01	3.29e-03	4.20e-01
91Mu Exclusive	CTD Exclusive	5.33e-01	6.20e-01	1.70e-01	4.52e-08
CTD Exclusive	91Mu Exclusive	2.88e-02	7.62e-01	1.92e-02	6.06e-01
91Mu Exclusive	Overlap	8.09e-01	9.26e-01	9.41e-01	5.96e-01
CTD Exclusive	Overlap	1.69e-04	1.02e-02	1.69e-04	1.95e-04
Overlap	Exclusives	1.64e-08	2.07e-09	6.02e-24	1.16e-16



Evaluating how well 91Mu genes are linked to CTD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91Mu Exclusive	CTD	0.67	-0.29	-0.71	-0.63	5.76
CTD Exclusive	91Mu	0.52	0.93	0.17	0.45	0.91
91Mu Exclusive	CTD Exclusive	0.67	-0.23	-0.71	-0.63	6.35
CTD Exclusive	91Mu Exclusive	0.50	0.71	-0.19	-0.38	0.03
91Mu Exclusive	Overlap	0.62	-0.89	-0.34	-0.69	1.02
CTD Exclusive	Overlap	1.00	2.65	2.16	2.78	3.17
Overlap	Exclusives	0.70	6.07	7.10	2.94	9.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91Mu Exclusive	CTD	0.01	-0.67	-0.72	-0.76	1.90
CTD Exclusive	91Mu	0.01	37.03	20.93	14.64	5.97
91Mu Exclusive	CTD Exclusive	0.01	-0.68	-0.76	-0.93	4.17
CTD Exclusive	91Mu Exclusive	0.00	0.01	-0.47	-0.81	-0.57
91Mu Exclusive	Overlap	0.00	-0.63	-0.08	-0.61	-0.11
CTD Exclusive	Overlap	0.22	337.17	508.68	530.33	1087.20
Overlap	Exclusives	0.06	29.05	53.45	23.92	52.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91Mu Exclusive	87	87	
CTD Exclusive	99	85	MIR708;CTR1C;MIR146A;MIR296;MIR124A-3;MIR4467;MIR766;MIR100;ATP7;MIR3622B;MIR375;CTR1B;MIR505;SNAR-I
Overlap	4	4