Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
omim	ConsensusHighestUnion	2.85e-01	2.05e-01	2.01e-03	1.89e-05
ConsensusHighestUnion	omim	9.23e-02	3.44e-01	1.23e-03	1.14e-03



Evaluating how well omim genes are linked to ConsensusHighestUnion genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
omim	ConsensusHighestUnion	0.74	1.33	2.38	1.67	5.29
ConsensusHighestUnion	omim	0.74	-0.50	1.44	1.15	4.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
omim	ConsensusHighestUnion	0.00	-0.36	0.92	1.95	4.09
ConsensusHighestUnion	omim	0.00	-0.14	2.37	2.29	5.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
omim	29	29	
ConsensusHighestUnion	35	35