Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Omim Exclusive	MediumOnly-Clustering	4.18e-05	3.10e-04	8.01e-13	6.47e-10
MediumOnly-Clustering Exclusive	Omim	7.69e-05	3.16e-05	8.35e-09	1.56e-10
Omim Exclusive	MediumOnly-Clustering Exclusive	1.96e-04	4.80e-04	9.48e-11	2.14e-09
MediumOnly-Clustering Exclusive	Omim Exclusive	9.92e-06	2.43e-05	1.84e-09	1.30e-11
Omim Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
MediumOnly-Clustering Exclusive	Overlap	5.84e-01	6.48e-01	5.63e-01	2.46e-01
Overlap	Exclusives	5.03e-02	5.08e-02	2.69e-16	5.25e-11



Evaluating how well Omim genes are linked to MediumOnly-Clustering genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Omim Exclusive	MediumOnly-Clustering	0.65	2.67	3.96	2.28	6.66
MediumOnly-Clustering Exclusive	Omim	0.87	2.24	5.16	3.07	7.23
Omim Exclusive	MediumOnly-Clustering Exclusive	0.64	2.80	4.00	2.29	7.57
MediumOnly-Clustering Exclusive	Omim Exclusive	0.89	3.06	5.63	3.21	7.28
Omim Exclusive	Overlap	1.00	3.05	2.62	2.57	3.18
MediumOnly-Clustering Exclusive	Overlap	0.69	-0.54	0.38	0.46	1.33
Overlap	Exclusives	0.64	1.01	2.42	0.94	7.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Omim Exclusive	MediumOnly-Clustering	0.04	8.24	21.10	17.38	29.96
MediumOnly-Clustering Exclusive	Omim	0.01	0.87	8.04	5.13	13.27
Omim Exclusive	MediumOnly-Clustering Exclusive	0.02	5.55	8.47	6.80	14.82
MediumOnly-Clustering Exclusive	Omim Exclusive	0.01	0.57	7.03	4.77	6.58
Omim Exclusive	Overlap	0.72	2197.86	1343.50	2249.81	3299.17
MediumOnly-Clustering Exclusive	Overlap	0.00	-0.66	-0.49	-0.12	0.08
Overlap	Exclusives	0.03	5.12	15.22	4.94	20.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Omim Exclusive	26	26	
MediumOnly-Clustering Exclusive	210	210	
Overlap	3	3