Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
108Female Exclusive	25GS	3.91e-02	4.34e-02	1.22e-02	4.15e-01
25GS Exclusive	108Female	4.03e-03	9.10e-02	4.99e-01	1.81e-01
108Female Exclusive	25GS Exclusive	4.71e-02	3.74e-02	1.75e-02	2.55e-01
25GS Exclusive	108Female Exclusive	1.91e-03	8.52e-02	2.81e-01	5.87e-02
108Female Exclusive	Overlap	7.54e-01	3.51e-01	7.01e-01	4.89e-01
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	8.63e-02	1.96e-02	1.25e-12	2.14e-02



Evaluating how well 108Female genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
108Female Exclusive	25GS	0.49	-1.52	-2.96	-2.15	-0.27
25GS Exclusive	108Female	0.48	-1.40	-1.38	-1.44	-0.74
108Female Exclusive	25GS Exclusive	0.47	-1.89	-3.15	-1.81	-0.43
25GS Exclusive	108Female Exclusive	0.47	-1.69	-1.51	-1.30	-1.18
108Female Exclusive	Overlap	0.68	-0.23	-0.40	-0.26	1.01
25GS Exclusive	Overlap	1.00	2.59	1.97	2.11	2.38
Overlap	Exclusives	0.57	3.07	2.34	1.95	2.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
108Female Exclusive	25GS	0.00	-1.04	-1.45	-1.20	-0.90
25GS Exclusive	108Female	0.01	-0.10	0.30	0.18	0.52
108Female Exclusive	25GS Exclusive	0.00	-1.33	-1.20	-0.46	-0.63
25GS Exclusive	108Female Exclusive	0.00	-1.42	-1.46	-1.24	-1.22
108Female Exclusive	Overlap	0.00	-0.57	-0.87	-0.70	-0.03
25GS Exclusive	Overlap	0.05	120.29	190.05	37.49	96.82
Overlap	Exclusives	0.02	9.05	19.77	13.70	11.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
108Female Exclusive	106	104	RAB6D;RFPL2
25GS Exclusive	23	22	HLA -DRB1
Overlap	2	2