Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
108Female Exclusive	CTD	2.41e-02	6.52e-03	1.86e-03	7.30e-04
CTD Exclusive	108Female	2.35e-04	7.78e-01	1.56e-01	5.56e-01
108Female Exclusive	CTD Exclusive	2.48e-02	9.91e-03	1.26e-02	1.26e-03
CTD Exclusive	108Female Exclusive	1.22e-04	4.42e-01	4.08e-01	1.86e-01
108Female Exclusive	Overlap	2.25e-01	2.74e-01	2.63e-01	7.41e-01
CTD Exclusive	Overlap	1.02e-02	8.53e-02	7.14e-04	1.65e-03
Overlap	Exclusives	1.28e-07	2.58e-10	9.16e-19	2.20e-15



Evaluating how well 108Female genes are linked to CTD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
108Female Exclusive	CTD	0.61	-1.78	-3.95	-2.28	3.78
CTD Exclusive	108Female	0.49	-0.86	-0.74	-0.72	-0.37
108Female Exclusive	CTD Exclusive	0.62	-2.16	-3.79	-2.10	4.18
CTD Exclusive	108Female Exclusive	0.47	-1.28	-1.19	-1.00	-0.99
108Female Exclusive	Overlap	0.49	-1.48	-1.74	-1.35	-0.05
CTD Exclusive	Overlap	0.95	3.28	2.48	3.00	3.48
Overlap	Exclusives	0.68	4.30	6.53	2.94	8.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
108Female Exclusive	CTD	0.01	-1.42	-3.42	-1.53	0.58
CTD Exclusive	108Female	0.01	14.11	5.74	6.36	2.83
108Female Exclusive	CTD Exclusive	0.01	-1.75	-3.26	-1.45	2.28
CTD Exclusive	108Female Exclusive	0.00	-1.54	-1.22	-1.06	-1.49
108Female Exclusive	Overlap	0.00	-0.50	-1.07	-0.94	-0.37
CTD Exclusive	Overlap	0.10	249.27	307.67	279.19	574.61
Overlap	Exclusives	0.04	18.94	29.17	14.87	33.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
108Female Exclusive	104	102	RAB6D;RFPL2
CTD Exclusive	99	85	CTR1B;MIR375;SNAR-I;ATP7;MIR3622B;MIR505;MIR146A;MIR708;MIR4467;MIR100;MIR766;CTR1C;MIR124A-3;MIR296
Overlap	4	4