Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
108Female Exclusive	clinvar	3.86e-01	8.64e-01	1.35e-01	5.08e-02
clinvar Exclusive	108Female	9.87e-03	3.26e-01	1.77e-04	4.63e-01
108Female Exclusive	clinvar Exclusive	2.61e-01	7.37e-01	1.96e-01	8.02e-02
clinvar Exclusive	108Female Exclusive	6.94e-03	3.46e-01	4.22e-05	2.38e-01
108Female Exclusive	Overlap	6.11e-01	9.92e-02	7.14e-01	1.18e-01
clinvar Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	3.05e-03	4.68e-02	6.50e-28	4.25e-02



Evaluating how well 108Female genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
108Female Exclusive	clinvar	0.63	-0.70	-0.59	-1.08	2.25
clinvar Exclusive	108Female	0.49	-0.17	-0.75	-0.67	-0.42
108Female Exclusive	clinvar Exclusive	0.62	-1.03	-0.72	-1.16	1.95
clinvar Exclusive	108Female Exclusive	0.48	-0.43	-0.85	-0.63	-0.60
108Female Exclusive	Overlap	0.92	0.50	-100974770728373.67	0.36	1.83
clinvar Exclusive	Overlap	1.00	1.86	inf	1.73	1.70
Overlap	Exclusives	0.55	105049308573244.00	1.28	0.95	2.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
108Female Exclusive	clinvar	0.00	-0.61	-0.70	-1.00	1.03
clinvar Exclusive	108Female	0.01	1.11	2.26	2.22	3.28
108Female Exclusive	clinvar Exclusive	0.00	-1.22	-0.66	-0.86	0.24
clinvar Exclusive	108Female Exclusive	0.01	0.14	0.53	0.27	-0.12
108Female Exclusive	Overlap	0.00	-0.22	-inf	-0.26	0.22
clinvar Exclusive	Overlap	0.04	123.68	169448680032092768.00	147.25	106.73
Overlap	Exclusives	0.01	554311908059906.00	5.61	3.94	6.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
108Female Exclusive	107	105	RAB6D;RFPL2
clinvar Exclusive	20	20	
Overlap	1	1