Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OMIM Exclusive	Consensus_DefaultCluster	2.34e-07	1.50e-07	5.32e-24	1.04e-16
Consensus_DefaultCluster Exclusive	OMIM	9.30e-04	4.14e-03	3.20e-08	2.85e-08
OMIM Exclusive	Consensus_DefaultCluster Exclusive	1.56e-06	4.67e-07	2.79e-22	3.08e-16
Consensus_DefaultCluster Exclusive	OMIM Exclusive	1.69e-03	1.20e-03	2.42e-08	1.51e-07
OMIM Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.69e-04
Consensus_DefaultCluster Exclusive	Overlap	3.05e-01	4.02e-01	1.87e-01	3.47e-02
Overlap	Exclusives	3.67e-02	1.41e-02	8.04e-28	5.99e-23



Evaluating how well OMIM genes are linked to Consensus_DefaultCluster genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OMIM Exclusive	Consensus_DefaultCluster	0.65	2.05	5.63	2.32	10.31
Consensus_DefaultCluster Exclusive	OMIM	0.84	1.78	3.86	2.55	6.25
OMIM Exclusive	Consensus_DefaultCluster Exclusive	0.64	1.74	4.42	2.17	11.50
Consensus_DefaultCluster Exclusive	OMIM Exclusive	0.85	1.77	3.82	2.57	6.23
OMIM Exclusive	Overlap	1.00	3.17	2.86	3.34	3.97
Consensus_DefaultCluster Exclusive	Overlap	0.76	-0.22	0.71	0.95	1.88
Overlap	Exclusives	0.65	1.08	4.60	1.14	12.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OMIM Exclusive	Consensus_DefaultCluster	0.05	3.96	15.29	9.23	26.09
Consensus_DefaultCluster Exclusive	OMIM	0.01	1.64	3.36	4.21	8.92
OMIM Exclusive	Consensus_DefaultCluster Exclusive	0.04	2.22	7.79	5.55	18.68
Consensus_DefaultCluster Exclusive	OMIM Exclusive	0.01	0.90	3.58	3.91	0.95
OMIM Exclusive	Overlap	0.59	1710.79	1057.99	2782.05	1135.35
Consensus_DefaultCluster Exclusive	Overlap	0.00	0.60	0.63	1.58	0.71
Overlap	Exclusives	0.05	3.45	13.21	3.85	25.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OMIM Exclusive	25	25	
Consensus_DefaultCluster Exclusive	465	456	KIF1BP (KIAA1279);PLPP4 (PPAPDC1A);TRMO (C9orf156);ADGRE1 (EMR1);ARMT1 (C6orf211);SEM1 (SHFM1);ADA2 (CECR1);PLPP5 (PPAPDC1B);MRE11 (MRE11A)
Overlap	4	4