Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GWASCatalog Exclusive	Consensus_DefaultClustering	1.21e-07	3.74e-07	1.80e-24	3.93e-17
Consensus_DefaultClustering Exclusive	GWASCatalog	1.16e-03	8.87e-03	3.27e-08	7.18e-08
GWASCatalog Exclusive	Consensus_DefaultClustering Exclusive	9.67e-07	6.77e-07	5.01e-23	4.45e-16
Consensus_DefaultClustering Exclusive	GWASCatalog Exclusive	1.47e-03	1.71e-03	3.50e-08	1.03e-07
GWASCatalog Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.69e-04
Consensus_DefaultClustering Exclusive	Overlap	3.37e-01	2.98e-01	1.83e-01	6.84e-02
Overlap	Exclusives	2.85e-02	1.48e-02	1.55e-32	6.33e-23



Evaluating how well GWASCatalog genes are linked to Consensus_DefaultClustering genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GWASCatalog Exclusive	Consensus_DefaultClustering	0.65	1.76	5.59	2.54	11.55
Consensus_DefaultClustering Exclusive	GWASCatalog	0.84	1.44	3.88	2.59	7.12
GWASCatalog Exclusive	Consensus_DefaultClustering Exclusive	0.64	1.68	5.12	2.32	10.87
Consensus_DefaultClustering Exclusive	GWASCatalog Exclusive	0.85	1.79	3.73	2.56	7.09
GWASCatalog Exclusive	Overlap	1.00	2.84	3.00	3.57	3.66
Consensus_DefaultClustering Exclusive	Overlap	0.76	-0.11	0.85	1.10	1.73
Overlap	Exclusives	0.65	1.44	3.89	1.24	11.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GWASCatalog Exclusive	Consensus_DefaultClustering	0.05	4.71	15.16	9.24	28.40
Consensus_DefaultClustering Exclusive	GWASCatalog	0.01	1.05	4.12	4.63	13.95
GWASCatalog Exclusive	Consensus_DefaultClustering Exclusive	0.04	2.14	8.57	5.39	19.34
Consensus_DefaultClustering Exclusive	GWASCatalog Exclusive	0.01	1.19	3.34	3.25	16.04
GWASCatalog Exclusive	Overlap	0.59	1519.09	822.70	2801.37	1144.50
Consensus_DefaultClustering Exclusive	Overlap	0.00	0.39	1.08	2.27	0.41
Overlap	Exclusives	0.05	4.25	11.53	3.68	22.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GWASCatalog Exclusive	25	25	
Consensus_DefaultClustering Exclusive	465	456	KIF1BP (KIAA1279);ADGRE1 (EMR1);PLPP4 (PPAPDC1A);ADA2 (CECR1);TRMO (C9orf156);MRE11 (MRE11A);ARMT1 (C6orf211);SEM1 (SHFM1);PLPP5 (PPAPDC1B)
Overlap	4	4