Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
APOE3	CLINVAR	4.22e-02	5.94e-02	3.77e-02	7.93e-07
CLINVAR	APOE3	1.12e-03	7.97e-01	7.96e-09	4.33e-01



Evaluating how well APOE3 genes are linked to CLINVAR genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE3	CLINVAR	0.81	1.94	2.44	1.56	4.97
CLINVAR	APOE3	0.51	-0.02	0.27	0.39	0.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
APOE3	CLINVAR	0.01	0.56	0.99	0.89	7.96
CLINVAR	APOE3	0.02	2.07	4.16	3.35	3.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
APOE3	251	250	RFPL2
CLINVAR	21	21