Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Hispanic Exclusive	GS25	5.66e-01	3.05e-01	5.27e-01	2.77e-01
GS25 Exclusive	Hispanic	1.92e-02	4.78e-01	4.26e-01	5.56e-01
Hispanic Exclusive	GS25 Exclusive	3.02e-01	2.27e-01	4.32e-01	3.20e-01
GS25 Exclusive	Hispanic Exclusive	9.36e-03	3.14e-01	6.93e-01	4.43e-01
Hispanic Exclusive	Overlap	6.77e-01	5.17e-01	6.61e-01	3.46e-02
GS25 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.79e-01	5.13e-02	3.01e-36	2.37e-02



Evaluating how well Hispanic genes are linked to GS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Hispanic Exclusive	GS25	0.57	-0.71	-1.11	-0.75	1.02
GS25 Exclusive	Hispanic	0.50	-0.68	-1.15	-0.98	0.04
Hispanic Exclusive	GS25 Exclusive	0.54	-1.17	-1.46	-1.02	0.83
GS25 Exclusive	Hispanic Exclusive	0.50	-0.92	-1.25	-1.04	-0.10
Hispanic Exclusive	Overlap	0.93	1.05	1.14	1.06	2.07
GS25 Exclusive	Overlap	1.00	2.66	2.36	2.59	2.41
Overlap	Exclusives	0.56	2.93	2.12	1.88	3.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Hispanic Exclusive	GS25	0.00	-0.51	-0.50	-0.48	0.39
GS25 Exclusive	Hispanic	0.01	0.09	-0.22	-0.10	0.01
Hispanic Exclusive	GS25 Exclusive	0.00	-0.68	-0.73	-0.55	-0.03
GS25 Exclusive	Hispanic Exclusive	0.01	-0.74	-0.96	-0.85	-0.53
Hispanic Exclusive	Overlap	0.00	-0.21	-2.52	-0.10	0.01
GS25 Exclusive	Overlap	0.04	74.45	208.50	140.23	118.36
Overlap	Exclusives	0.03	44.55	19.85	22.62	32.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Hispanic Exclusive	203	203	
GS25 Exclusive	23	23	
Overlap	2	2