Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
African Exclusive	174MuGenes	5.18e-01	9.19e-02	1.20e-01	9.48e-02
174MuGenes Exclusive	African	2.65e-01	5.55e-01	3.14e-01	6.50e-02
African Exclusive	174MuGenes Exclusive	2.81e-01	1.75e-01	1.40e-01	1.69e-01
174MuGenes Exclusive	African Exclusive	2.44e-01	6.29e-01	3.69e-01	1.06e-01
African Exclusive	Overlap	7.70e-01	4.77e-01	4.87e-01	1.57e-02
174MuGenes Exclusive	Overlap	6.34e-01	1.45e-01	5.12e-01	2.04e-01
Overlap	Exclusives	4.08e-01	8.74e-01	6.61e-22	4.42e-01



Evaluating how well African genes are linked to 174MuGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
African Exclusive	174MuGenes	0.55	1.67	2.47	2.15	2.16
174MuGenes Exclusive	African	0.53	0.85	0.51	0.55	1.64
African Exclusive	174MuGenes Exclusive	0.54	1.90	1.94	1.77	1.71
174MuGenes Exclusive	African Exclusive	0.52	1.24	0.66	0.87	1.42
African Exclusive	Overlap	0.74	0.81	1.32	1.07	2.89
174MuGenes Exclusive	Overlap	0.65	-0.40	-0.73	-0.59	1.49
Overlap	Exclusives	0.52	-1.83	0.12	0.47	1.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
African Exclusive	174MuGenes	0.01	0.63	2.25	0.73	1.57
174MuGenes Exclusive	African	0.01	2.66	2.11	2.54	2.95
African Exclusive	174MuGenes Exclusive	0.01	0.52	1.94	0.39	0.83
174MuGenes Exclusive	African Exclusive	0.01	2.85	1.94	2.35	1.47
African Exclusive	Overlap	0.00	0.57	-2.70	0.98	1.26
174MuGenes Exclusive	Overlap	0.00	4.41	2.10	4.66	7.58
Overlap	Exclusives	0.02	-0.33	0.99	0.67	1.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
African Exclusive	192	192	
174MuGenes Exclusive	164	160	SOS 2;AC004754.1;RFPL2;PRAMEF11
Overlap	10	10