Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial	1.02e-17	6.18e-14	7.07e-33	2.49e-30
BRCA-familial Exclusive	MCL_Inflat2_1_ClustersAtLeast8	6.28e-15	1.79e-12	2.24e-79	4.89e-41
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial Exclusive	2.04e-04	2.35e-04	1.78e-21	6.56e-12
BRCA-familial Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	2.76e-12	1.37e-10	1.09e-74	4.56e-39
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	1.46e-33	6.89e-15	1.46e-33	1.69e-29
BRCA-familial Exclusive	Overlap	1.46e-33	2.03e-24	2.18e-32	1.19e-27
Overlap	Exclusives	2.48e-24	1.77e-17	4.46e-35	4.26e-37



Evaluating how well MCL_Inflat2_1_ClustersAtLeast8 genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial	0.99	4.29	6.94	4.00	9.22
BRCA-familial Exclusive	MCL_Inflat2_1_ClustersAtLeast8	0.75	1.92	8.14	2.45	16.52
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial Exclusive	0.98	3.67	3.99	3.24	5.03
BRCA-familial Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	0.74	2.07	7.41	1.96	17.38
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	1.00	4.80	6.82	3.41	6.49
BRCA-familial Exclusive	Overlap	1.00	2.37	6.39	2.90	5.60
Overlap	Exclusives	0.74	2.57	9.25	3.12	16.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial	0.22	13.25	139.83	28.96	50.00
BRCA-familial Exclusive	MCL_Inflat2_1_ClustersAtLeast8	0.13	6.82	70.23	21.24	106.23
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial Exclusive	0.01	-0.94	2.51	4.47	40.91
BRCA-familial Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	0.08	5.58	35.22	10.33	76.84
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	0.29	11.21	340.11	17.42	762.59
BRCA-familial Exclusive	Overlap	0.40	52.62	651.62	409.61	830.62
Overlap	Exclusives	0.12	11.99	71.40	28.32	106.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	390	389	
BRCA-familial Exclusive	9	9	
Overlap	14	14