Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial-unique	1.32e-17	1.49e-13	5.51e-36	5.04e-21
BRCA-familial-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8	6.33e-13	6.98e-13	2.33e-67	8.43e-47
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial-unique Exclusive	4.80e-05	1.27e-04	2.98e-14	8.82e-09
BRCA-familial-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	2.64e-11	2.84e-11	1.96e-74	9.82e-45
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	1.78e-21	1.68e-13	1.78e-21	2.04e-17
BRCA-familial-unique Exclusive	Overlap	1.78e-21	1.46e-15	1.78e-21	1.27e-18
Overlap	Exclusives	5.27e-18	3.53e-19	1.26e-26	1.09e-40



Evaluating how well MCL_Inflat2_1_ClustersAtLeast8 genes are linked to BRCA-familial-unique genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial-unique	0.99	4.34	6.26	3.67	7.40
BRCA-familial-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8	0.76	2.77	9.50	2.45	19.85
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial-unique Exclusive	0.99	4.15	3.30	3.30	4.59
BRCA-familial-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	0.75	3.31	8.51	2.45	18.23
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	1.00	4.90	5.07	3.18	5.12
BRCA-familial-unique Exclusive	Overlap	1.00	3.25	5.01	2.40	5.34
Overlap	Exclusives	0.74	2.81	9.00	2.24	16.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial-unique	0.19	207.22	114.40	374.42	674.71
BRCA-familial-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8	0.13	9.37	69.82	19.62	112.32
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-familial-unique Exclusive	0.02	9.51	4.97	32.14	35.50
BRCA-familial-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	0.09	10.92	45.93	12.20	84.88
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	0.24	507.37	318.69	584.05	124.77
BRCA-familial-unique Exclusive	Overlap	0.31	93.70	781.39	370.37	1229.62
Overlap	Exclusives	0.13	15.19	78.05	22.74	109.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	395	394	
BRCA-familial-unique Exclusive	6	6	
Overlap	9	9