Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-somatic-unique	1.30e-01	1.64e-01	1.73e-09	6.93e-13
BRCA-somatic-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8	2.07e-07	2.80e-04	4.91e-30	4.05e-22
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-somatic-unique Exclusive	6.00e-01	2.44e-01	3.62e-08	4.71e-10
BRCA-somatic-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	5.22e-07	5.65e-04	8.08e-31	2.97e-21
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	8.41e-03	1.85e-01	1.83e-09	1.62e-05
BRCA-somatic-unique Exclusive	Overlap	6.40e-08	3.84e-07	1.83e-09	2.30e-07
Overlap	Exclusives	1.33e-10	3.30e-06	2.33e-139	9.67e-43



Evaluating how well MCL_Inflat2_1_ClustersAtLeast8 genes are linked to BRCA-somatic-unique genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-somatic-unique	0.90	0.13	2.57	1.77	6.86
BRCA-somatic-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8	0.67	-0.26	3.60	0.95	13.37
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-somatic-unique Exclusive	0.88	0.07	2.16	2.10	5.97
BRCA-somatic-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	0.67	-0.03	3.25	0.84	11.99
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	0.98	0.37	1.76	1.40	3.91
BRCA-somatic-unique Exclusive	Overlap	0.99	1.44	2.79	2.63	3.31
Overlap	Exclusives	0.72	1.14	6.94	1.57	16.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-somatic-unique	0.01	-1.50	3.14	-0.54	6.31
BRCA-somatic-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8	0.04	-0.13	5.20	2.68	18.11
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	BRCA-somatic-unique Exclusive	0.01	-1.28	0.85	-0.54	5.20
BRCA-somatic-unique Exclusive	MCL_Inflat2_1_ClustersAtLeast8 Exclusive	0.04	-0.05	4.55	2.80	15.87
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	Overlap	0.00	-2.15	4.11	-0.10	9.44
BRCA-somatic-unique Exclusive	Overlap	0.01	0.76	24.78	23.64	17.16
Overlap	Exclusives	0.06	3.60	19.08	4.91	40.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MCL_Inflat2_1_ClustersAtLeast8 Exclusive	400	399	
BRCA-somatic-unique Exclusive	21	21	
Overlap	4	4