Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus2	AS_risk	8.53e-02	2.27e-01	1.17e-02	3.06e-02
AS_risk	consensus2	6.53e-01	1.42e-02	1.62e-06	8.47e-09



Evaluating how well consensus2 genes are linked to AS_risk genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus2	AS_risk	0.75	1.81	1.81	1.96	2.92
AS_risk	consensus2	0.66	0.84	2.74	1.01	6.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus2	AS_risk	0.00	2.52	0.76	3.00	1.89
AS_risk	consensus2	0.01	0.26	1.00	1.14	7.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus2	116	115	AL355102.2
AS_risk	9	9