Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus2 Exclusive	GWAS_review_all	1.97e-02	2.67e-02	8.30e-07	2.11e-06
GWAS_review_all Exclusive	consensus2	7.79e-03	7.24e-04	6.08e-08	5.32e-08
consensus2 Exclusive	GWAS_review_all Exclusive	3.36e-02	5.30e-02	1.02e-06	2.47e-06
GWAS_review_all Exclusive	consensus2 Exclusive	2.61e-02	1.28e-03	6.47e-07	9.32e-08
consensus2 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
GWAS_review_all Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.27e-07	1.29e-10	2.31e-25	3.24e-20



Evaluating how well consensus2 genes are linked to GWAS_review_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus2 Exclusive	GWAS_review_all	0.66	2.97	2.70	2.27	5.41
GWAS_review_all Exclusive	consensus2	0.67	1.54	3.69	2.27	5.84
consensus2 Exclusive	GWAS_review_all Exclusive	0.66	2.90	2.39	2.28	5.05
GWAS_review_all Exclusive	consensus2 Exclusive	0.66	1.42	4.02	1.85	5.38
consensus2 Exclusive	Overlap	1.00	1.85	2.31	1.44	1.61
GWAS_review_all Exclusive	Overlap	1.00	1.89	1.97	1.66	1.58
Overlap	Exclusives	0.72	2.43	9.30	2.74	10.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus2 Exclusive	GWAS_review_all	0.01	4.40	4.34	4.69	8.98
GWAS_review_all Exclusive	consensus2	0.02	3.27	10.58	6.31	9.75
consensus2 Exclusive	GWAS_review_all Exclusive	0.01	3.16	2.30	3.58	4.53
GWAS_review_all Exclusive	consensus2 Exclusive	0.01	1.95	7.92	4.82	6.79
consensus2 Exclusive	Overlap	0.02	85.75	368.51	34.79	6.45
GWAS_review_all Exclusive	Overlap	0.06	206.60	323.98	195.88	102.07
Overlap	Exclusives	0.05	15.02	51.24	14.70	50.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus2 Exclusive	115	114	AL355102.2
GWAS_review_all Exclusive	95	95	
Overlap	1	1