Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus2 Exclusive	all_IS	1.30e-01	1.18e-01	2.03e-05	2.02e-04
all_IS Exclusive	consensus2	1.62e-02	8.61e-03	6.29e-06	1.45e-06
consensus2 Exclusive	all_IS Exclusive	1.49e-01	1.65e-01	6.61e-05	2.94e-04
all_IS Exclusive	consensus2 Exclusive	2.48e-02	1.27e-02	1.27e-04	9.10e-07
consensus2 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
all_IS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.68e-07	1.13e-08	3.05e-18	1.47e-15



Evaluating how well consensus2 genes are linked to all_IS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus2 Exclusive	all_IS	0.67	2.79	2.54	2.69	4.35
all_IS Exclusive	consensus2	0.67	1.75	3.79	2.28	6.43
consensus2 Exclusive	all_IS Exclusive	0.66	2.65	2.08	2.48	3.85
all_IS Exclusive	consensus2 Exclusive	0.67	1.85	3.72	2.19	6.29
consensus2 Exclusive	Overlap	1.00	1.93	2.33	1.44	1.73
all_IS Exclusive	Overlap	1.00	1.72	1.88	1.89	1.62
Overlap	Exclusives	0.71	2.49	7.38	2.41	9.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus2 Exclusive	all_IS	0.01	3.24	4.28	6.53	1.92
all_IS Exclusive	consensus2	0.01	3.25	8.38	5.68	11.64
consensus2 Exclusive	all_IS Exclusive	0.01	2.09	1.08	4.05	3.57
all_IS Exclusive	consensus2 Exclusive	0.01	1.06	5.88	3.10	6.19
consensus2 Exclusive	Overlap	0.02	70.37	397.05	31.25	35.46
all_IS Exclusive	Overlap	0.08	399.94	951.36	574.08	315.99
Overlap	Exclusives	0.05	20.11	56.93	15.01	59.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus2 Exclusive	115	114	AL355102.2
all_IS Exclusive	65	57	CDKN2B-AS1;LOC100505841;PRMD16;FURIN-FES;LINC00924;3p12;PRMD8;LRHC1
Overlap	1	1