Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
5Method Exclusive	GWASCatalog	5.14e-04	4.97e-01	1.70e-31	4.28e-11
GWASCatalog Exclusive	5Method	4.32e-04	7.89e-04	3.15e-23	2.70e-29
5Method Exclusive	GWASCatalog Exclusive	1.35e-04	8.80e-01	7.88e-26	1.91e-08
GWASCatalog Exclusive	5Method Exclusive	3.94e-03	6.05e-02	2.44e-19	7.41e-25
5Method Exclusive	Overlap	5.02e-03	2.50e-03	3.59e-10	5.50e-11
GWASCatalog Exclusive	Overlap	8.85e-10	2.42e-09	5.57e-15	3.25e-15
Overlap	Exclusives	1.05e-37	3.97e-26	5.37e-86	1.13e-64



Evaluating how well 5Method genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5Method Exclusive	GWASCatalog	0.60	1.49	0.83	3.73	8.33
GWASCatalog Exclusive	5Method	0.67	-0.00	2.84	2.03	12.93
5Method Exclusive	GWASCatalog Exclusive	0.59	1.09	-0.07	2.65	6.51
GWASCatalog Exclusive	5Method Exclusive	0.66	-0.51	2.07	1.88	13.50
5Method Exclusive	Overlap	0.82	4.58	4.85	4.08	6.04
GWASCatalog Exclusive	Overlap	0.85	5.29	4.95	5.00	7.12
Overlap	Exclusives	0.69	7.34	15.30	7.73	21.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5Method Exclusive	GWASCatalog	0.04	1.25	2.05	4.36	11.17
GWASCatalog Exclusive	5Method	0.07	3.53	12.82	6.15	31.78
5Method Exclusive	GWASCatalog Exclusive	0.04	0.95	0.15	2.98	6.87
GWASCatalog Exclusive	5Method Exclusive	0.05	-0.19	4.73	2.74	22.71
5Method Exclusive	Overlap	0.01	3.22	9.56	4.53	22.08
GWASCatalog Exclusive	Overlap	0.12	57.44	119.39	115.81	133.46
Overlap	Exclusives	0.14	15.81	41.98	22.31	62.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
5Method Exclusive	536	536	
GWASCatalog Exclusive	513	510	IG2BP2;C5orf67;INAFM2
Overlap	35	35