Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
6Method Exclusive	Yahaya	1.86e-02	1.29e-01	1.86e-06	8.40e-12
Yahaya Exclusive	6Method	3.25e-05	1.85e-08	2.08e-35	1.85e-34
6Method Exclusive	Yahaya Exclusive	2.33e-01	2.60e-01	4.43e-05	4.10e-09
Yahaya Exclusive	6Method Exclusive	9.60e-04	3.51e-08	3.37e-32	3.77e-32
6Method Exclusive	Overlap	6.55e-03	2.37e-02	2.52e-04	1.69e-04
Yahaya Exclusive	Overlap	2.77e-12	4.02e-09	2.11e-14	6.58e-12
Overlap	Exclusives	3.91e-23	6.56e-22	4.55e-64	6.10e-40



Evaluating how well 6Method genes are linked to Yahaya genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
6Method Exclusive	Yahaya	0.75	1.10	1.85	1.56	7.19
Yahaya Exclusive	6Method	0.67	2.35	7.29	4.00	12.38
6Method Exclusive	Yahaya Exclusive	0.73	0.71	1.15	1.28	6.52
Yahaya Exclusive	6Method Exclusive	0.66	2.02	7.00	3.03	13.39
6Method Exclusive	Overlap	0.84	2.03	2.72	1.93	4.61
Yahaya Exclusive	Overlap	0.97	4.99	5.88	4.30	6.34
Overlap	Exclusives	0.69	4.24	9.71	3.00	16.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
6Method Exclusive	Yahaya	0.02	0.30	10.64	2.83	8.91
Yahaya Exclusive	6Method	0.06	2.24	10.83	7.54	22.15
6Method Exclusive	Yahaya Exclusive	0.02	-0.29	7.22	2.12	41.14
Yahaya Exclusive	6Method Exclusive	0.05	0.48	5.89	3.41	15.73
6Method Exclusive	Overlap	0.01	4.44	9.82	5.12	17.26
Yahaya Exclusive	Overlap	0.22	282.14	226.27	403.40	739.05
Overlap	Exclusives	0.12	16.97	54.98	20.89	75.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
6Method Exclusive	568	567	TMEM189-UBE2V1
Yahaya Exclusive	59	59	
Overlap	13	13