Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
6Method Exclusive	GWASCatalog	8.56e-04	7.66e-01	1.11e-27	4.10e-11
GWASCatalog Exclusive	6Method	7.37e-03	1.50e-02	1.40e-20	5.89e-23
6Method Exclusive	GWASCatalog Exclusive	2.01e-04	9.78e-01	2.00e-22	1.96e-08
GWASCatalog Exclusive	6Method Exclusive	1.15e-03	4.28e-01	1.12e-15	2.22e-19
6Method Exclusive	Overlap	2.44e-03	5.89e-03	3.93e-08	3.68e-07
GWASCatalog Exclusive	Overlap	1.23e-08	1.12e-08	3.13e-13	1.47e-13
Overlap	Exclusives	4.31e-36	3.07e-29	4.13e-77	1.05e-59



Evaluating how well 6Method genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
6Method Exclusive	GWASCatalog	0.60	1.80	0.84	2.99	9.86
GWASCatalog Exclusive	6Method	0.65	0.02	3.06	2.19	13.05
6Method Exclusive	GWASCatalog Exclusive	0.59	0.53	-0.04	2.30	6.54
GWASCatalog Exclusive	6Method Exclusive	0.64	-0.77	1.90	1.53	12.06
6Method Exclusive	Overlap	0.80	4.14	4.52	4.48	5.57
GWASCatalog Exclusive	Overlap	0.84	4.89	4.27	5.38	7.72
Overlap	Exclusives	0.68	7.25	14.34	7.24	22.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
6Method Exclusive	GWASCatalog	0.04	0.86	1.67	3.47	12.21
GWASCatalog Exclusive	6Method	0.07	3.89	13.57	7.09	35.52
6Method Exclusive	GWASCatalog Exclusive	0.04	0.05	-0.08	2.49	6.88
GWASCatalog Exclusive	6Method Exclusive	0.05	-0.84	3.33	1.70	16.46
6Method Exclusive	Overlap	0.01	3.00	9.62	5.04	2.82
GWASCatalog Exclusive	Overlap	0.14	77.45	136.93	121.92	242.39
Overlap	Exclusives	0.14	17.59	43.56	24.04	66.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
6Method Exclusive	545	544	TMEM189-UBE2V1
GWASCatalog Exclusive	512	509	INAFM2;IG2BP2;C5orf67
Overlap	36	36