Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ACC_ReactomeCoreGenes Exclusive	ACC_BaileyGenes	4.49e-01	3.16e-01	8.14e-03	4.24e-03
ACC_BaileyGenes Exclusive	ACC_ReactomeCoreGenes	3.71e-01	4.92e-01	1.75e-05	3.31e-04
ACC_ReactomeCoreGenes Exclusive	ACC_BaileyGenes Exclusive	5.96e-01	8.29e-01	3.60e-02	1.19e-02
ACC_BaileyGenes Exclusive	ACC_ReactomeCoreGenes Exclusive	6.38e-01	4.69e-01	6.92e-06	1.13e-03
ACC_ReactomeCoreGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ACC_BaileyGenes Exclusive	Overlap	1.58e-01	1.98e-02	1.98e-02	7.92e-02
Overlap	Exclusives	6.40e-05	1.65e-04	2.12e-14	1.15e-09



Evaluating how well ACC_ReactomeCoreGenes genes are linked to ACC_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ACC_ReactomeCoreGenes Exclusive	ACC_BaileyGenes	0.92	0.90	1.47	2.12	3.07
ACC_BaileyGenes Exclusive	ACC_ReactomeCoreGenes	0.81	0.96	0.99	0.71	3.94
ACC_ReactomeCoreGenes Exclusive	ACC_BaileyGenes Exclusive	0.90	0.92	1.19	2.06	2.72
ACC_BaileyGenes Exclusive	ACC_ReactomeCoreGenes Exclusive	0.79	0.86	0.85	0.67	3.72
ACC_ReactomeCoreGenes Exclusive	Overlap	1.00	1.13	inf	1.80	1.81
ACC_BaileyGenes Exclusive	Overlap	0.99	0.93	42383532353348.00	2.19	1.58
Overlap	Exclusives	0.93	796480062666983.00	4.25	2.36	5.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ACC_ReactomeCoreGenes Exclusive	ACC_BaileyGenes	0.01	2.84	13.58	24.58	10.27
ACC_BaileyGenes Exclusive	ACC_ReactomeCoreGenes	0.00	1.29	0.85	0.51	5.55
ACC_ReactomeCoreGenes Exclusive	ACC_BaileyGenes Exclusive	0.00	-0.11	0.37	3.59	2.08
ACC_BaileyGenes Exclusive	ACC_ReactomeCoreGenes Exclusive	0.00	0.87	0.54	1.04	2.65
ACC_ReactomeCoreGenes Exclusive	Overlap	0.03	12.84	302095750781747648.00	165.14	53.89
ACC_BaileyGenes Exclusive	Overlap	0.00	1.92	inf	10.97	0.57
Overlap	Exclusives	0.02	35708837518477808.00	29.54	19.89	24.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ACC_ReactomeCoreGenes Exclusive	13	13	
ACC_BaileyGenes Exclusive	4	4	
Overlap	1	1