Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
CESC_ReactomeCoreGenes Exclusive	CESC_BaileyGenes	2.45e-11	1.07e-06	1.47e-27	3.00e-21
CESC_BaileyGenes Exclusive	CESC_ReactomeCoreGenes	2.39e-20	2.91e-14	8.15e-48	7.31e-35
CESC_ReactomeCoreGenes Exclusive	CESC_BaileyGenes Exclusive	5.64e-08	1.79e-05	1.09e-18	2.21e-15
CESC_BaileyGenes Exclusive	CESC_ReactomeCoreGenes Exclusive	8.81e-19	1.91e-13	1.59e-43	3.20e-32
CESC_ReactomeCoreGenes Exclusive	Overlap	2.23e-06	4.09e-03	2.98e-14	1.62e-09
CESC_BaileyGenes Exclusive	Overlap	9.33e-05	4.09e-03	3.34e-05	1.09e-04
Overlap	Exclusives	6.23e-25	2.04e-23	2.25e-48	8.62e-42



Evaluating how well CESC_ReactomeCoreGenes genes are linked to CESC_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CESC_ReactomeCoreGenes Exclusive	CESC_BaileyGenes	0.96	2.99	4.41	4.03	8.20
CESC_BaileyGenes Exclusive	CESC_ReactomeCoreGenes	0.91	5.20	9.82	5.44	14.26
CESC_ReactomeCoreGenes Exclusive	CESC_BaileyGenes Exclusive	0.96	2.37	3.78	3.51	7.62
CESC_BaileyGenes Exclusive	CESC_ReactomeCoreGenes Exclusive	0.91	4.98	8.53	5.14	11.71
CESC_ReactomeCoreGenes Exclusive	Overlap	0.99	1.98	2.48	3.14	4.18
CESC_BaileyGenes Exclusive	Overlap	0.96	1.01	2.52	2.93	4.05
Overlap	Exclusives	0.92	3.93	11.46	3.63	13.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CESC_ReactomeCoreGenes Exclusive	CESC_BaileyGenes	0.20	3.81	127.53	92.79	238.80
CESC_BaileyGenes Exclusive	CESC_ReactomeCoreGenes	0.10	8.77	51.99	77.24	183.20
CESC_ReactomeCoreGenes Exclusive	CESC_BaileyGenes Exclusive	0.09	0.32	81.51	52.94	199.80
CESC_BaileyGenes Exclusive	CESC_ReactomeCoreGenes Exclusive	0.08	8.70	52.15	58.78	143.13
CESC_ReactomeCoreGenes Exclusive	Overlap	0.22	23.06	201.24	308.31	360.58
CESC_BaileyGenes Exclusive	Overlap	0.04	1.66	73.24	118.61	39.13
Overlap	Exclusives	0.09	13.16	46.18	35.29	71.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
CESC_ReactomeCoreGenes Exclusive	72	72	
CESC_BaileyGenes Exclusive	20	20	
Overlap	6	6