Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
COADREAD_ReactomeCoreGenes Exclusive	COADREAD_BaileyGenes	1.56e-06	3.57e-04	7.98e-16	4.44e-13
COADREAD_BaileyGenes Exclusive	COADREAD_ReactomeCoreGenes	1.57e-19	2.82e-12	8.40e-43	5.56e-37
COADREAD_ReactomeCoreGenes Exclusive	COADREAD_BaileyGenes Exclusive	1.40e-03	9.93e-04	4.12e-10	1.31e-08
COADREAD_BaileyGenes Exclusive	COADREAD_ReactomeCoreGenes Exclusive	9.55e-18	2.47e-11	2.90e-39	2.67e-34
COADREAD_ReactomeCoreGenes Exclusive	Overlap	1.27e-06	3.17e-02	7.45e-12	3.26e-08
COADREAD_BaileyGenes Exclusive	Overlap	4.47e-11	7.20e-04	1.57e-10	9.39e-10
Overlap	Exclusives	3.62e-13	1.24e-20	2.46e-45	5.63e-39



Evaluating how well COADREAD_ReactomeCoreGenes genes are linked to COADREAD_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
COADREAD_ReactomeCoreGenes Exclusive	COADREAD_BaileyGenes	0.94	2.22	4.03	3.75	6.31
COADREAD_BaileyGenes Exclusive	COADREAD_ReactomeCoreGenes	0.86	4.20	9.86	4.64	13.80
COADREAD_ReactomeCoreGenes Exclusive	COADREAD_BaileyGenes Exclusive	0.93	1.73	3.26	3.08	6.01
COADREAD_BaileyGenes Exclusive	COADREAD_ReactomeCoreGenes Exclusive	0.85	5.14	9.72	4.44	13.55
COADREAD_ReactomeCoreGenes Exclusive	Overlap	0.99	2.99	1.61	2.06	3.51
COADREAD_BaileyGenes Exclusive	Overlap	1.00	3.18	2.21	3.65	3.62
Overlap	Exclusives	0.87	2.92	11.00	3.43	13.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
COADREAD_ReactomeCoreGenes Exclusive	COADREAD_BaileyGenes	0.16	5.09	90.58	101.11	154.33
COADREAD_BaileyGenes Exclusive	COADREAD_ReactomeCoreGenes	0.06	10.19	26.82	30.15	39.39
COADREAD_ReactomeCoreGenes Exclusive	COADREAD_BaileyGenes Exclusive	0.11	3.69	114.03	69.99	452.48
COADREAD_BaileyGenes Exclusive	COADREAD_ReactomeCoreGenes Exclusive	0.05	11.78	22.51	20.29	39.03
COADREAD_ReactomeCoreGenes Exclusive	Overlap	0.07	8.49	35.96	64.10	288.72
COADREAD_BaileyGenes Exclusive	Overlap	0.06	27.69	34.68	126.38	231.88
Overlap	Exclusives	0.07	6.13	66.96	23.82	57.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
COADREAD_ReactomeCoreGenes Exclusive	114	114	
COADREAD_BaileyGenes Exclusive	15	15	
Overlap	5	5