Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
DLBC_ReactomeCoreGenes Exclusive	DLBC_BaileyGenes	3.55e-01	3.69e-01	6.53e-02	1.33e-03
DLBC_BaileyGenes Exclusive	DLBC_ReactomeCoreGenes	3.22e-04	4.49e-05	8.68e-09	3.07e-09
DLBC_ReactomeCoreGenes Exclusive	DLBC_BaileyGenes Exclusive	3.75e-01	4.22e-01	6.62e-02	2.66e-03
DLBC_BaileyGenes Exclusive	DLBC_ReactomeCoreGenes Exclusive	1.45e-03	3.28e-04	7.00e-08	1.24e-07
DLBC_ReactomeCoreGenes Exclusive	Overlap	9.17e-01	9.89e-01	6.61e-01	2.11e-01
DLBC_BaileyGenes Exclusive	Overlap	4.89e-02	1.52e-01	2.07e-02	5.42e-03
Overlap	Exclusives	2.98e-01	5.52e-03	1.22e-07	2.09e-08



Evaluating how well DLBC_ReactomeCoreGenes genes are linked to DLBC_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
DLBC_ReactomeCoreGenes Exclusive	DLBC_BaileyGenes	0.80	1.60	1.79	1.46	3.39
DLBC_BaileyGenes Exclusive	DLBC_ReactomeCoreGenes	0.87	3.25	4.82	2.70	5.96
DLBC_ReactomeCoreGenes Exclusive	DLBC_BaileyGenes Exclusive	0.81	1.87	1.88	1.91	3.22
DLBC_BaileyGenes Exclusive	DLBC_ReactomeCoreGenes Exclusive	0.86	2.97	4.19	2.60	5.10
DLBC_ReactomeCoreGenes Exclusive	Overlap	0.77	0.60	-0.07	0.33	1.43
DLBC_BaileyGenes Exclusive	Overlap	0.96	1.44	2.41	1.85	2.35
Overlap	Exclusives	0.83	1.24	3.54	1.28	5.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
DLBC_ReactomeCoreGenes Exclusive	DLBC_BaileyGenes	0.00	0.93	4.47	3.93	6.45
DLBC_BaileyGenes Exclusive	DLBC_ReactomeCoreGenes	0.00	4.25	5.31	4.16	4.39
DLBC_ReactomeCoreGenes Exclusive	DLBC_BaileyGenes Exclusive	0.00	0.71	7.82	5.43	5.52
DLBC_BaileyGenes Exclusive	DLBC_ReactomeCoreGenes Exclusive	0.00	2.66	2.04	3.25	6.45
DLBC_ReactomeCoreGenes Exclusive	Overlap	0.00	-0.17	-0.74	-0.15	0.27
DLBC_BaileyGenes Exclusive	Overlap	0.00	0.44	6.87	1.26	4.91
Overlap	Exclusives	0.00	1.02	4.75	0.90	4.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
DLBC_ReactomeCoreGenes Exclusive	16	16	
DLBC_BaileyGenes Exclusive	11	11	
Overlap	2	2