Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ESCA_ReactomeCoreGenes Exclusive	ESCA_BaileyGenes	6.89e-05	8.47e-04	5.64e-12	2.43e-11
ESCA_BaileyGenes Exclusive	ESCA_ReactomeCoreGenes	1.26e-06	9.17e-12	7.42e-45	9.95e-33
ESCA_ReactomeCoreGenes Exclusive	ESCA_BaileyGenes Exclusive	7.04e-04	3.17e-02	2.16e-08	2.77e-08
ESCA_BaileyGenes Exclusive	ESCA_ReactomeCoreGenes Exclusive	2.32e-06	3.55e-11	2.26e-44	3.73e-31
ESCA_ReactomeCoreGenes Exclusive	Overlap	2.60e-02	9.07e-03	4.36e-07	1.59e-04
ESCA_BaileyGenes Exclusive	Overlap	1.74e-06	1.14e-02	4.36e-07	1.74e-06
Overlap	Exclusives	5.23e-19	1.15e-15	2.50e-67	7.15e-39



Evaluating how well ESCA_ReactomeCoreGenes genes are linked to ESCA_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ESCA_ReactomeCoreGenes Exclusive	ESCA_BaileyGenes	0.96	3.72	4.18	3.56	6.00
ESCA_BaileyGenes Exclusive	ESCA_ReactomeCoreGenes	0.80	2.65	10.60	3.84	12.16
ESCA_ReactomeCoreGenes Exclusive	ESCA_BaileyGenes Exclusive	0.95	3.31	2.86	2.83	5.20
ESCA_BaileyGenes Exclusive	ESCA_ReactomeCoreGenes Exclusive	0.80	2.36	10.26	3.63	14.38
ESCA_ReactomeCoreGenes Exclusive	Overlap	0.99	0.07	10.50	1.55	2.84
ESCA_BaileyGenes Exclusive	Overlap	1.00	1.82	3.68	3.16	2.84
Overlap	Exclusives	0.82	2.84	9.41	2.65	14.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ESCA_ReactomeCoreGenes Exclusive	ESCA_BaileyGenes	0.06	-0.45	11.10	19.52	71.82
ESCA_BaileyGenes Exclusive	ESCA_ReactomeCoreGenes	0.05	5.45	29.12	19.67	46.58
ESCA_ReactomeCoreGenes Exclusive	ESCA_BaileyGenes Exclusive	0.03	-0.97	6.46	12.54	99.54
ESCA_BaileyGenes Exclusive	ESCA_ReactomeCoreGenes Exclusive	0.05	4.56	22.71	15.50	35.10
ESCA_ReactomeCoreGenes Exclusive	Overlap	0.09	7.24	22.80	56.99	47.53
ESCA_BaileyGenes Exclusive	Overlap	0.02	6.93	20.34	65.66	36.27
Overlap	Exclusives	0.06	8.75	33.54	10.38	52.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ESCA_ReactomeCoreGenes Exclusive	163	163	
ESCA_BaileyGenes Exclusive	10	10	
Overlap	3	3