Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LGG_ReactomeCoreGenes Exclusive	LGG_BaileyGenes	5.02e-07	5.42e-04	9.08e-16	6.02e-13
LGG_BaileyGenes Exclusive	LGG_ReactomeCoreGenes	3.93e-08	1.99e-09	7.11e-51	4.29e-45
LGG_ReactomeCoreGenes Exclusive	LGG_BaileyGenes Exclusive	6.41e-03	1.44e-01	1.13e-09	2.04e-08
LGG_BaileyGenes Exclusive	LGG_ReactomeCoreGenes Exclusive	1.96e-06	1.48e-08	3.44e-51	5.86e-42
LGG_ReactomeCoreGenes Exclusive	Overlap	2.98e-14	2.03e-06	2.98e-14	6.26e-12
LGG_BaileyGenes Exclusive	Overlap	1.88e-04	6.14e-04	4.17e-07	4.27e-06
Overlap	Exclusives	4.55e-42	6.26e-30	1.15e-59	4.88e-63



Evaluating how well LGG_ReactomeCoreGenes genes are linked to LGG_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LGG_ReactomeCoreGenes Exclusive	LGG_BaileyGenes	0.92	1.72	3.78	4.07	7.27
LGG_BaileyGenes Exclusive	LGG_ReactomeCoreGenes	0.85	1.99	8.98	3.55	15.41
LGG_ReactomeCoreGenes Exclusive	LGG_BaileyGenes Exclusive	0.89	0.96	2.90	3.14	6.04
LGG_BaileyGenes Exclusive	LGG_ReactomeCoreGenes Exclusive	0.85	2.01	7.56	4.23	13.99
LGG_ReactomeCoreGenes Exclusive	Overlap	1.00	2.53	3.99	2.77	4.11
LGG_BaileyGenes Exclusive	Overlap	0.98	3.10	3.35	3.23	4.20
Overlap	Exclusives	0.91	4.50	11.61	3.13	17.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LGG_ReactomeCoreGenes Exclusive	LGG_BaileyGenes	0.21	9.39	141.40	84.02	188.29
LGG_BaileyGenes Exclusive	LGG_ReactomeCoreGenes	0.09	9.76	43.71	28.73	126.43
LGG_ReactomeCoreGenes Exclusive	LGG_BaileyGenes Exclusive	0.03	-0.74	22.66	14.70	71.69
LGG_BaileyGenes Exclusive	LGG_ReactomeCoreGenes Exclusive	0.06	7.24	25.39	31.40	93.07
LGG_ReactomeCoreGenes Exclusive	Overlap	0.45	46.15	756.11	418.88	569.76
LGG_BaileyGenes Exclusive	Overlap	0.18	48.81	306.79	328.24	430.90
Overlap	Exclusives	0.09	21.28	50.66	19.56	131.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LGG_ReactomeCoreGenes Exclusive	131	131	
LGG_BaileyGenes Exclusive	18	18	
Overlap	6	6