Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LUAD_ReactomeCoreGenes Exclusive	LUAD_BaileyGenes	6.26e-02	4.56e-02	2.63e-09	8.98e-10
LUAD_BaileyGenes Exclusive	LUAD_ReactomeCoreGenes	8.00e-07	2.26e-03	3.55e-43	7.04e-28
LUAD_ReactomeCoreGenes Exclusive	LUAD_BaileyGenes Exclusive	7.33e-02	7.69e-02	1.09e-08	3.29e-09
LUAD_BaileyGenes Exclusive	LUAD_ReactomeCoreGenes Exclusive	5.75e-07	2.58e-03	4.78e-45	3.70e-27
LUAD_ReactomeCoreGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
LUAD_BaileyGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	6.43e-09	8.28e-20	1.11e-189	9.14e-76



Evaluating how well LUAD_ReactomeCoreGenes genes are linked to LUAD_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LUAD_ReactomeCoreGenes Exclusive	LUAD_BaileyGenes	0.89	-2.14	2.01	1.37	6.35
LUAD_BaileyGenes Exclusive	LUAD_ReactomeCoreGenes	0.72	0.26	3.65	1.75	14.02
LUAD_ReactomeCoreGenes Exclusive	LUAD_BaileyGenes Exclusive	0.89	-2.06	1.74	1.28	5.38
LUAD_BaileyGenes Exclusive	LUAD_ReactomeCoreGenes Exclusive	0.72	0.33	4.09	1.72	15.39
LUAD_ReactomeCoreGenes Exclusive	Overlap	1.00	-1.52	31970655187200.50	0.87	1.88
LUAD_BaileyGenes Exclusive	Overlap	0.99	0.60	inf	1.55	1.60
Overlap	Exclusives	0.81	152577129866682.00	14.19	1.85	20.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LUAD_ReactomeCoreGenes Exclusive	LUAD_BaileyGenes	0.01	-3.11	4.63	-0.37	16.22
LUAD_BaileyGenes Exclusive	LUAD_ReactomeCoreGenes	0.05	0.75	8.22	7.57	34.83
LUAD_ReactomeCoreGenes Exclusive	LUAD_BaileyGenes Exclusive	0.01	-2.77	0.31	-0.52	19.83
LUAD_BaileyGenes Exclusive	LUAD_ReactomeCoreGenes Exclusive	0.05	0.62	7.51	7.49	35.58
LUAD_ReactomeCoreGenes Exclusive	Overlap	0.01	-1.03	23675753441120220.00	1.63	48.40
LUAD_BaileyGenes Exclusive	Overlap	0.00	-0.13	11693341316565554.00	12.83	5.90
Overlap	Exclusives	0.07	1570486562706663.00	31.82	2.79	43.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LUAD_ReactomeCoreGenes Exclusive	326	326	
LUAD_BaileyGenes Exclusive	19	19	
Overlap	1	1