Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LUSC_ReactomeCoreGenes Exclusive	LUSC_BaileyGenes	1.81e-03	6.71e-03	1.32e-12	4.82e-17
LUSC_BaileyGenes Exclusive	LUSC_ReactomeCoreGenes	2.02e-07	1.30e-08	1.79e-51	3.83e-36
LUSC_ReactomeCoreGenes Exclusive	LUSC_BaileyGenes Exclusive	6.48e-02	3.60e-03	2.37e-10	2.66e-13
LUSC_BaileyGenes Exclusive	LUSC_ReactomeCoreGenes Exclusive	2.39e-07	1.02e-08	4.01e-49	4.38e-34
LUSC_ReactomeCoreGenes Exclusive	Overlap	7.92e-04	3.75e-02	3.96e-07	2.85e-05
LUSC_BaileyGenes Exclusive	Overlap	7.20e-04	3.17e-02	2.81e-06	1.75e-05
Overlap	Exclusives	7.53e-24	2.35e-28	7.74e-87	6.56e-52



Evaluating how well LUSC_ReactomeCoreGenes genes are linked to LUSC_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LUSC_ReactomeCoreGenes Exclusive	LUSC_BaileyGenes	0.95	1.42	3.53	3.05	7.94
LUSC_BaileyGenes Exclusive	LUSC_ReactomeCoreGenes	0.78	1.72	8.55	2.94	14.65
LUSC_ReactomeCoreGenes Exclusive	LUSC_BaileyGenes Exclusive	0.94	0.87	3.13	3.23	5.95
LUSC_BaileyGenes Exclusive	LUSC_ReactomeCoreGenes Exclusive	0.77	1.84	8.23	2.77	14.30
LUSC_ReactomeCoreGenes Exclusive	Overlap	0.98	1.28	1.69	1.63	3.29
LUSC_BaileyGenes Exclusive	Overlap	0.98	1.47	2.07	2.86	3.98
Overlap	Exclusives	0.82	2.67	12.16	2.29	18.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LUSC_ReactomeCoreGenes Exclusive	LUSC_BaileyGenes	0.02	-2.36	8.08	2.04	27.81
LUSC_BaileyGenes Exclusive	LUSC_ReactomeCoreGenes	0.06	1.24	24.30	14.15	67.56
LUSC_ReactomeCoreGenes Exclusive	LUSC_BaileyGenes Exclusive	0.01	-1.89	3.38	1.17	37.84
LUSC_BaileyGenes Exclusive	LUSC_ReactomeCoreGenes Exclusive	0.05	0.69	20.09	10.68	50.43
LUSC_ReactomeCoreGenes Exclusive	Overlap	0.02	-1.42	10.23	2.36	20.03
LUSC_BaileyGenes Exclusive	Overlap	0.11	32.24	266.29	187.67	465.53
Overlap	Exclusives	0.08	4.94	36.17	9.43	59.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LUSC_ReactomeCoreGenes Exclusive	227	227	
LUSC_BaileyGenes Exclusive	17	17	
Overlap	5	5