Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MESO_ReactomeCoreGenes	MESO_BaileyGenes	7.70e-01	4.49e-01	6.17e-01	3.96e-02
MESO_BaileyGenes	MESO_ReactomeCoreGenes	3.20e-01	5.46e-01	4.54e-05	2.06e-01



Evaluating how well MESO_ReactomeCoreGenes genes are linked to MESO_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MESO_ReactomeCoreGenes	MESO_BaileyGenes	0.72	-0.38	0.33	-0.59	1.82
MESO_BaileyGenes	MESO_ReactomeCoreGenes	0.52	0.27	-0.35	-0.15	0.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MESO_ReactomeCoreGenes	MESO_BaileyGenes	0.00	-0.24	-0.03	-0.35	-0.04
MESO_BaileyGenes	MESO_ReactomeCoreGenes	0.00	-0.21	-0.43	-0.27	-0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MESO_ReactomeCoreGenes	7	7	
MESO_BaileyGenes	5	5