Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OV_ReactomeCoreGenes Exclusive	OV_BaileyGenes	1.48e-01	6.30e-02	2.65e-04	1.29e-04
OV_BaileyGenes Exclusive	OV_ReactomeCoreGenes	1.05e-03	4.08e-03	1.66e-44	1.29e-23
OV_ReactomeCoreGenes Exclusive	OV_BaileyGenes Exclusive	4.81e-01	2.22e-01	1.97e-02	4.53e-03
OV_BaileyGenes Exclusive	OV_ReactomeCoreGenes Exclusive	1.19e-03	4.45e-03	1.85e-47	1.31e-23
OV_ReactomeCoreGenes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
OV_BaileyGenes Exclusive	Overlap	2.07e-03	9.85e-05	2.96e-04	9.85e-04
Overlap	Exclusives	1.61e-15	1.83e-11	6.56e-95	2.04e-49



Evaluating how well OV_ReactomeCoreGenes genes are linked to OV_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OV_ReactomeCoreGenes Exclusive	OV_BaileyGenes	0.92	2.17	2.58	2.76	4.21
OV_BaileyGenes Exclusive	OV_ReactomeCoreGenes	0.72	-0.50	3.02	0.61	11.62
OV_ReactomeCoreGenes Exclusive	OV_BaileyGenes Exclusive	0.90	1.86	1.95	2.61	3.23
OV_BaileyGenes Exclusive	OV_ReactomeCoreGenes Exclusive	0.72	-0.72	2.96	0.69	11.48
OV_ReactomeCoreGenes Exclusive	Overlap	1.00	1.24	701988086812964.00	1.13	2.35
OV_BaileyGenes Exclusive	Overlap	0.98	1.66	358569074593343.00	2.57	2.49
Overlap	Exclusives	0.81	192957696585435.50	9.90	1.96	16.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OV_ReactomeCoreGenes Exclusive	OV_BaileyGenes	0.04	-0.19	12.13	6.83	64.68
OV_BaileyGenes Exclusive	OV_ReactomeCoreGenes	0.02	0.86	3.92	1.78	15.36
OV_ReactomeCoreGenes Exclusive	OV_BaileyGenes Exclusive	0.00	-1.05	-2.27	-0.35	3.72
OV_BaileyGenes Exclusive	OV_ReactomeCoreGenes Exclusive	0.02	0.58	3.16	1.92	11.48
OV_ReactomeCoreGenes Exclusive	Overlap	0.12	16.80	31214722506718836.00	44.11	555.87
OV_BaileyGenes Exclusive	Overlap	0.00	1.98	inf	4.41	0.57
Overlap	Exclusives	0.05	2949857499010897.00	29.07	4.97	35.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OV_ReactomeCoreGenes Exclusive	211	211	
OV_BaileyGenes Exclusive	6	6	
Overlap	2	2