Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PAAD_ReactomeCoreGenes Exclusive	PAAD_BaileyGenes	2.13e-04	4.27e-03	1.92e-07	4.87e-07
PAAD_BaileyGenes Exclusive	PAAD_ReactomeCoreGenes	4.66e-03	9.29e-05	1.54e-14	2.40e-11
PAAD_ReactomeCoreGenes Exclusive	PAAD_BaileyGenes Exclusive	1.42e-03	1.04e-02	2.50e-06	1.21e-06
PAAD_BaileyGenes Exclusive	PAAD_ReactomeCoreGenes Exclusive	6.97e-03	2.04e-04	2.65e-13	5.83e-11
PAAD_ReactomeCoreGenes Exclusive	Overlap	1.98e-02	6.34e-01	1.98e-02	5.94e-02
PAAD_BaileyGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.81e-04	2.49e-05	4.31e-14	6.66e-13



Evaluating how well PAAD_ReactomeCoreGenes genes are linked to PAAD_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PAAD_ReactomeCoreGenes Exclusive	PAAD_BaileyGenes	0.93	1.97	3.25	4.46	5.06
PAAD_BaileyGenes Exclusive	PAAD_ReactomeCoreGenes	0.92	3.34	5.26	3.49	7.03
PAAD_ReactomeCoreGenes Exclusive	PAAD_BaileyGenes Exclusive	0.93	1.55	2.69	2.81	5.29
PAAD_BaileyGenes Exclusive	PAAD_ReactomeCoreGenes Exclusive	0.92	3.27	6.02	3.46	5.90
PAAD_ReactomeCoreGenes Exclusive	Overlap	0.98	1.80	1.25	2.06	1.58
PAAD_BaileyGenes Exclusive	Overlap	1.00	1.70	2.25	2.44	1.68
Overlap	Exclusives	0.88	2.11	3.76	1.78	7.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PAAD_ReactomeCoreGenes Exclusive	PAAD_BaileyGenes	0.02	4.05	11.13	48.51	17.60
PAAD_BaileyGenes Exclusive	PAAD_ReactomeCoreGenes	0.02	11.50	19.52	37.98	53.74
PAAD_ReactomeCoreGenes Exclusive	PAAD_BaileyGenes Exclusive	0.02	3.36	15.64	30.69	57.47
PAAD_BaileyGenes Exclusive	PAAD_ReactomeCoreGenes Exclusive	0.02	10.56	27.20	24.90	58.57
PAAD_ReactomeCoreGenes Exclusive	Overlap	0.00	7.83	0.49	7.73	2.29
PAAD_BaileyGenes Exclusive	Overlap	0.01	17.84	30.70	31.38	20.64
Overlap	Exclusives	0.01	4.44	10.72	2.73	16.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PAAD_ReactomeCoreGenes Exclusive	21	21	
PAAD_BaileyGenes Exclusive	10	10	
Overlap	1	1