Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PCPG_BaileyGenes Exclusive	Overlap or PCPG_ReactomeCoreGenes	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap or PCPG_ReactomeCoreGenes	PCPG_BaileyGenes Exclusive	1.10e-02	8.41e-03	4.95e-04	7.48e-05



Evaluating how well PCPG_ReactomeCoreGenes genes are linked to PCPG_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PCPG_BaileyGenes Exclusive	Overlap or PCPG_ReactomeCoreGenes	0.99	9.31	1.35	2.15	1.75
Overlap or PCPG_ReactomeCoreGenes	PCPG_BaileyGenes Exclusive	0.97	2.99	3.61	2.41	3.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PCPG_BaileyGenes Exclusive	Overlap or PCPG_ReactomeCoreGenes	0.00	85.78	15.44	12.73	21.24
Overlap or PCPG_ReactomeCoreGenes	PCPG_BaileyGenes Exclusive	0.00	6.94	26.75	0.74	9.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PCPG_ReactomeCoreGenes Exclusive	0	0	
PCPG_BaileyGenes Exclusive	4	4	
Overlap	1	1