Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STAD_ReactomeCoreGenes Exclusive	STAD_BaileyGenes	2.19e-09	1.62e-04	5.27e-20	3.22e-17
STAD_BaileyGenes Exclusive	STAD_ReactomeCoreGenes	5.37e-18	1.67e-22	9.74e-78	1.98e-59
STAD_ReactomeCoreGenes Exclusive	STAD_BaileyGenes Exclusive	2.28e-06	5.36e-03	4.66e-14	2.81e-12
STAD_BaileyGenes Exclusive	STAD_ReactomeCoreGenes Exclusive	1.67e-16	5.39e-22	6.17e-75	5.48e-58
STAD_ReactomeCoreGenes Exclusive	Overlap	7.20e-04	7.20e-04	7.45e-12	1.96e-07
STAD_BaileyGenes Exclusive	Overlap	4.17e-10	7.45e-12	7.45e-12	4.17e-10
Overlap	Exclusives	8.83e-31	3.20e-25	6.37e-74	1.11e-56



Evaluating how well STAD_ReactomeCoreGenes genes are linked to STAD_BaileyGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STAD_ReactomeCoreGenes Exclusive	STAD_BaileyGenes	0.90	2.22	3.25	3.05	6.80
STAD_BaileyGenes Exclusive	STAD_ReactomeCoreGenes	0.85	3.77	12.96	5.50	17.49
STAD_ReactomeCoreGenes Exclusive	STAD_BaileyGenes Exclusive	0.87	2.54	2.70	2.39	6.01
STAD_BaileyGenes Exclusive	STAD_ReactomeCoreGenes Exclusive	0.85	4.15	13.05	5.78	15.40
STAD_ReactomeCoreGenes Exclusive	Overlap	0.99	0.73	2.00	1.91	3.76
STAD_BaileyGenes Exclusive	Overlap	1.00	1.73	3.49	3.65	3.71
Overlap	Exclusives	0.85	4.26	14.58	3.55	18.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STAD_ReactomeCoreGenes Exclusive	STAD_BaileyGenes	0.22	7.60	46.33	42.01	284.89
STAD_BaileyGenes Exclusive	STAD_ReactomeCoreGenes	0.09	5.94	44.52	31.18	122.40
STAD_ReactomeCoreGenes Exclusive	STAD_BaileyGenes Exclusive	0.09	1.27	17.59	23.82	281.10
STAD_BaileyGenes Exclusive	STAD_ReactomeCoreGenes Exclusive	0.08	5.96	37.99	29.40	67.91
STAD_ReactomeCoreGenes Exclusive	Overlap	0.34	33.59	146.50	181.57	831.83
STAD_BaileyGenes Exclusive	Overlap	0.06	9.56	93.02	208.62	72.39
Overlap	Exclusives	0.12	14.93	60.95	24.62	132.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STAD_ReactomeCoreGenes Exclusive	192	192	
STAD_BaileyGenes Exclusive	19	19	
Overlap	5	5